Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery

We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in...

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Autores principales: Cosma, Stefano, Carosso, Andrea Roberto, Corcione, Silvia, Cusato, Jessica, Borella, Fulvio, Antonucci, Miriam, Marozio, Luca, Revelli, Alberto, Preti, Mario, Ghisetti, Valeria, Di Perri, Giovanni, Benedetto, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973007/
https://www.ncbi.nlm.nih.gov/pubmed/33582489
http://dx.doi.org/10.1016/j.jri.2021.103285
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author Cosma, Stefano
Carosso, Andrea Roberto
Corcione, Silvia
Cusato, Jessica
Borella, Fulvio
Antonucci, Miriam
Marozio, Luca
Revelli, Alberto
Preti, Mario
Ghisetti, Valeria
Di Perri, Giovanni
Benedetto, Chiara
author_facet Cosma, Stefano
Carosso, Andrea Roberto
Corcione, Silvia
Cusato, Jessica
Borella, Fulvio
Antonucci, Miriam
Marozio, Luca
Revelli, Alberto
Preti, Mario
Ghisetti, Valeria
Di Perri, Giovanni
Benedetto, Chiara
author_sort Cosma, Stefano
collection PubMed
description We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARS-CoV-2 antibody response may help to guide vaccination strategies in pregnancy.
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spelling pubmed-79730072021-03-19 Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery Cosma, Stefano Carosso, Andrea Roberto Corcione, Silvia Cusato, Jessica Borella, Fulvio Antonucci, Miriam Marozio, Luca Revelli, Alberto Preti, Mario Ghisetti, Valeria Di Perri, Giovanni Benedetto, Chiara J Reprod Immunol Short Communication We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARS-CoV-2 antibody response may help to guide vaccination strategies in pregnancy. Elsevier B.V. 2021-04 2021-02-02 /pmc/articles/PMC7973007/ /pubmed/33582489 http://dx.doi.org/10.1016/j.jri.2021.103285 Text en © 2021 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Cosma, Stefano
Carosso, Andrea Roberto
Corcione, Silvia
Cusato, Jessica
Borella, Fulvio
Antonucci, Miriam
Marozio, Luca
Revelli, Alberto
Preti, Mario
Ghisetti, Valeria
Di Perri, Giovanni
Benedetto, Chiara
Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery
title Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery
title_full Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery
title_fullStr Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery
title_full_unstemmed Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery
title_short Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery
title_sort longitudinal analysis of antibody response following sars-cov-2 infection in pregnancy: from the first trimester to delivery
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973007/
https://www.ncbi.nlm.nih.gov/pubmed/33582489
http://dx.doi.org/10.1016/j.jri.2021.103285
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