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Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double-strand break repair
We have previously shown that the tyrosine kinase inhibitors (TKIs) dasatinib and imatinib can protect salivary glands from irradiation (IR) damage without impacting tumor therapy. However, how they induce this protection is unknown. Here we show that TKIs mediate radioprotection by increasing the r...
Autores principales: | Affandi, Trisiani, Ohm, Angela M., Gaillard, Dany, Haas, Ami, Reyland, Mary E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973138/ https://www.ncbi.nlm.nih.gov/pubmed/33571522 http://dx.doi.org/10.1016/j.jbc.2021.100401 |
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