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Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome
FoxO1 is a member of the forkhead transcription factor family subgroup O (FoxO), which is expressed in many cell types, and participates in various pathophysiological processes, including cell proliferation, apoptosis, autophagy, metabolism, inflammatory response, cytokine expression, immune differe...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973228/ https://www.ncbi.nlm.nih.gov/pubmed/33746783 http://dx.doi.org/10.3389/fphys.2021.649295 |
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author | Xu, Renfeng Wang, Zhengchao |
author_facet | Xu, Renfeng Wang, Zhengchao |
author_sort | Xu, Renfeng |
collection | PubMed |
description | FoxO1 is a member of the forkhead transcription factor family subgroup O (FoxO), which is expressed in many cell types, and participates in various pathophysiological processes, including cell proliferation, apoptosis, autophagy, metabolism, inflammatory response, cytokine expression, immune differentiation, and oxidative stress resistance. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in the women of childbearing age, which is regulated via a variety of signaling pathways. Currently, the specific mechanism underlying the pathogenesis of PCOS is still unclear. As an important transcription factor, FoxO1 activity might be involved in the pathophysiology of PCOS. PCOS has been associated with insulin resistance and low-grade inflammatory response. Therefore, the studies regarding the role of FoxO1 in the incidence and associated complications of PCOS will help provide novel ideas for establishing the treatment strategy of PCOS. |
format | Online Article Text |
id | pubmed-7973228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79732282021-03-20 Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome Xu, Renfeng Wang, Zhengchao Front Physiol Physiology FoxO1 is a member of the forkhead transcription factor family subgroup O (FoxO), which is expressed in many cell types, and participates in various pathophysiological processes, including cell proliferation, apoptosis, autophagy, metabolism, inflammatory response, cytokine expression, immune differentiation, and oxidative stress resistance. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in the women of childbearing age, which is regulated via a variety of signaling pathways. Currently, the specific mechanism underlying the pathogenesis of PCOS is still unclear. As an important transcription factor, FoxO1 activity might be involved in the pathophysiology of PCOS. PCOS has been associated with insulin resistance and low-grade inflammatory response. Therefore, the studies regarding the role of FoxO1 in the incidence and associated complications of PCOS will help provide novel ideas for establishing the treatment strategy of PCOS. Frontiers Media S.A. 2021-03-05 /pmc/articles/PMC7973228/ /pubmed/33746783 http://dx.doi.org/10.3389/fphys.2021.649295 Text en Copyright © 2021 Xu and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Xu, Renfeng Wang, Zhengchao Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome |
title | Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome |
title_full | Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome |
title_fullStr | Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome |
title_full_unstemmed | Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome |
title_short | Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome |
title_sort | involvement of transcription factor foxo1 in the pathogenesis of polycystic ovary syndrome |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973228/ https://www.ncbi.nlm.nih.gov/pubmed/33746783 http://dx.doi.org/10.3389/fphys.2021.649295 |
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