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Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome

FoxO1 is a member of the forkhead transcription factor family subgroup O (FoxO), which is expressed in many cell types, and participates in various pathophysiological processes, including cell proliferation, apoptosis, autophagy, metabolism, inflammatory response, cytokine expression, immune differe...

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Detalles Bibliográficos
Autores principales: Xu, Renfeng, Wang, Zhengchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973228/
https://www.ncbi.nlm.nih.gov/pubmed/33746783
http://dx.doi.org/10.3389/fphys.2021.649295
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author Xu, Renfeng
Wang, Zhengchao
author_facet Xu, Renfeng
Wang, Zhengchao
author_sort Xu, Renfeng
collection PubMed
description FoxO1 is a member of the forkhead transcription factor family subgroup O (FoxO), which is expressed in many cell types, and participates in various pathophysiological processes, including cell proliferation, apoptosis, autophagy, metabolism, inflammatory response, cytokine expression, immune differentiation, and oxidative stress resistance. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in the women of childbearing age, which is regulated via a variety of signaling pathways. Currently, the specific mechanism underlying the pathogenesis of PCOS is still unclear. As an important transcription factor, FoxO1 activity might be involved in the pathophysiology of PCOS. PCOS has been associated with insulin resistance and low-grade inflammatory response. Therefore, the studies regarding the role of FoxO1 in the incidence and associated complications of PCOS will help provide novel ideas for establishing the treatment strategy of PCOS.
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spelling pubmed-79732282021-03-20 Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome Xu, Renfeng Wang, Zhengchao Front Physiol Physiology FoxO1 is a member of the forkhead transcription factor family subgroup O (FoxO), which is expressed in many cell types, and participates in various pathophysiological processes, including cell proliferation, apoptosis, autophagy, metabolism, inflammatory response, cytokine expression, immune differentiation, and oxidative stress resistance. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in the women of childbearing age, which is regulated via a variety of signaling pathways. Currently, the specific mechanism underlying the pathogenesis of PCOS is still unclear. As an important transcription factor, FoxO1 activity might be involved in the pathophysiology of PCOS. PCOS has been associated with insulin resistance and low-grade inflammatory response. Therefore, the studies regarding the role of FoxO1 in the incidence and associated complications of PCOS will help provide novel ideas for establishing the treatment strategy of PCOS. Frontiers Media S.A. 2021-03-05 /pmc/articles/PMC7973228/ /pubmed/33746783 http://dx.doi.org/10.3389/fphys.2021.649295 Text en Copyright © 2021 Xu and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Xu, Renfeng
Wang, Zhengchao
Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome
title Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome
title_full Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome
title_fullStr Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome
title_full_unstemmed Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome
title_short Involvement of Transcription Factor FoxO1 in the Pathogenesis of Polycystic Ovary Syndrome
title_sort involvement of transcription factor foxo1 in the pathogenesis of polycystic ovary syndrome
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973228/
https://www.ncbi.nlm.nih.gov/pubmed/33746783
http://dx.doi.org/10.3389/fphys.2021.649295
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