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Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems
Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers pro...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973310/ https://www.ncbi.nlm.nih.gov/pubmed/33763610 http://dx.doi.org/10.1016/j.heliyon.2021.e06436 |
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author | Fernández, Luciana Reviglio, Ana Lucía Heredia, Daniel A. Morales, Gustavo M. Santo, Marisa Otero, Luis Alustiza, Fabrisio Liaudat, Ana Cecilia Bosch, Pablo Larghi, Enrique L. Bracca, Andrea B.J. Kaufman, Teodoro S. |
author_facet | Fernández, Luciana Reviglio, Ana Lucía Heredia, Daniel A. Morales, Gustavo M. Santo, Marisa Otero, Luis Alustiza, Fabrisio Liaudat, Ana Cecilia Bosch, Pablo Larghi, Enrique L. Bracca, Andrea B.J. Kaufman, Teodoro S. |
author_sort | Fernández, Luciana |
collection | PubMed |
description | Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were grown over the monomolecular Langmuir-Blodgett films that acted as a drug reservoir and delivery system. The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures. |
format | Online Article Text |
id | pubmed-7973310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-79733102021-03-23 Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems Fernández, Luciana Reviglio, Ana Lucía Heredia, Daniel A. Morales, Gustavo M. Santo, Marisa Otero, Luis Alustiza, Fabrisio Liaudat, Ana Cecilia Bosch, Pablo Larghi, Enrique L. Bracca, Andrea B.J. Kaufman, Teodoro S. Heliyon Research Article Langmuir and Langmuir-Blodgett films holding a synthetic bioinspired wound healing active compound were used as drug-delivery platforms. Palmitic acid Langmuir monolayers were able to incorporate 2-methyltriclisine, a synthetic Triclisine derivative that showed wound healing activity. The layers proved to be stable and the nanocomposites were transferred to solid substrates. Normal human lung cells (Medical Research Council cell strain 5, MRC-5) were grown over the monomolecular Langmuir-Blodgett films that acted as a drug reservoir and delivery system. The proliferation and migration of the cells were clearly affected by the presence of 2-methyltriclisine in the amphiphilic layers. The methodology is proposed as a simple and reliable model for the study of the effects of bioactive compounds over cellular cultures. Elsevier 2021-03-14 /pmc/articles/PMC7973310/ /pubmed/33763610 http://dx.doi.org/10.1016/j.heliyon.2021.e06436 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Research Article Fernández, Luciana Reviglio, Ana Lucía Heredia, Daniel A. Morales, Gustavo M. Santo, Marisa Otero, Luis Alustiza, Fabrisio Liaudat, Ana Cecilia Bosch, Pablo Larghi, Enrique L. Bracca, Andrea B.J. Kaufman, Teodoro S. Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
title | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
title_full | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
title_fullStr | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
title_full_unstemmed | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
title_short | Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systems |
title_sort | langmuir-blodgett monolayers holding a wound healing active compound and its effect in cell culture. a model for the study of surface mediated drug delivery systems |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973310/ https://www.ncbi.nlm.nih.gov/pubmed/33763610 http://dx.doi.org/10.1016/j.heliyon.2021.e06436 |
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