Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease

Juvenile CLN3 disease is a recessively inherited paediatric neurodegenerative disorder, with most patients homozygous for a 1-kb intragenic deletion in CLN3. The btn1 gene is the Schizosaccharomyces pombe orthologue of CLN3. Here, we have extended the use of synthetic genetic array (SGA) analyses to...

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Detalles Bibliográficos
Autores principales: Minnis, Christopher J., Townsend, StJohn, Petschnigg, Julia, Tinelli, Elisa, Bähler, Jürg, Russell, Claire, Mole, Sara E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973434/
https://www.ncbi.nlm.nih.gov/pubmed/33737578
http://dx.doi.org/10.1038/s41598-021-85471-4

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