UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication

The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm(2) was sufficient to a...

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Autores principales: Biasin, Mara, Bianco, Andrea, Pareschi, Giovanni, Cavalleri, Adalberto, Cavatorta, Claudia, Fenizia, Claudio, Galli, Paola, Lessio, Luigi, Lualdi, Manuela, Tombetti, Enrico, Ambrosi, Alessandro, Redaelli, Edoardo Maria Alberto, Saulle, Irma, Trabattoni, Daria, Zanutta, Alessio, Clerici, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973506/
https://www.ncbi.nlm.nih.gov/pubmed/33737536
http://dx.doi.org/10.1038/s41598-021-85425-w
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author Biasin, Mara
Bianco, Andrea
Pareschi, Giovanni
Cavalleri, Adalberto
Cavatorta, Claudia
Fenizia, Claudio
Galli, Paola
Lessio, Luigi
Lualdi, Manuela
Tombetti, Enrico
Ambrosi, Alessandro
Redaelli, Edoardo Maria Alberto
Saulle, Irma
Trabattoni, Daria
Zanutta, Alessio
Clerici, Mario
author_facet Biasin, Mara
Bianco, Andrea
Pareschi, Giovanni
Cavalleri, Adalberto
Cavatorta, Claudia
Fenizia, Claudio
Galli, Paola
Lessio, Luigi
Lualdi, Manuela
Tombetti, Enrico
Ambrosi, Alessandro
Redaelli, Edoardo Maria Alberto
Saulle, Irma
Trabattoni, Daria
Zanutta, Alessio
Clerici, Mario
author_sort Biasin, Mara
collection PubMed
description The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm(2) was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9 mJ/cm(2). These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection.
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spelling pubmed-79735062021-03-19 UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication Biasin, Mara Bianco, Andrea Pareschi, Giovanni Cavalleri, Adalberto Cavatorta, Claudia Fenizia, Claudio Galli, Paola Lessio, Luigi Lualdi, Manuela Tombetti, Enrico Ambrosi, Alessandro Redaelli, Edoardo Maria Alberto Saulle, Irma Trabattoni, Daria Zanutta, Alessio Clerici, Mario Sci Rep Article The potential virucidal effects of UV-C irradiation on SARS-CoV-2 were experimentally evaluated for different illumination doses and virus concentrations (1000, 5, 0.05 MOI). At a virus density comparable to that observed in SARS-CoV-2 infection, an UV-C dose of just 3.7 mJ/cm(2) was sufficient to achieve a more than 3-log inactivation without any sign of viral replication. Moreover, a complete inactivation at all viral concentrations was observed with 16.9 mJ/cm(2). These results could explain the epidemiological trends of COVID-19 and are important for the development of novel sterilizing methods to contain SARS-CoV-2 infection. Nature Publishing Group UK 2021-03-18 /pmc/articles/PMC7973506/ /pubmed/33737536 http://dx.doi.org/10.1038/s41598-021-85425-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Biasin, Mara
Bianco, Andrea
Pareschi, Giovanni
Cavalleri, Adalberto
Cavatorta, Claudia
Fenizia, Claudio
Galli, Paola
Lessio, Luigi
Lualdi, Manuela
Tombetti, Enrico
Ambrosi, Alessandro
Redaelli, Edoardo Maria Alberto
Saulle, Irma
Trabattoni, Daria
Zanutta, Alessio
Clerici, Mario
UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication
title UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication
title_full UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication
title_fullStr UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication
title_full_unstemmed UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication
title_short UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication
title_sort uv-c irradiation is highly effective in inactivating sars-cov-2 replication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973506/
https://www.ncbi.nlm.nih.gov/pubmed/33737536
http://dx.doi.org/10.1038/s41598-021-85425-w
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