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Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex
Lexical retrieval requires selecting and retrieving the most appropriate word from the lexicon to express a desired concept. Few studies have probed lexical retrieval with tasks other than picture naming, and when non-picture naming lexical retrieval tasks have been applied, both convergent and dive...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973515/ https://www.ncbi.nlm.nih.gov/pubmed/33737672 http://dx.doi.org/10.1038/s41598-021-85802-5 |
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author | Aabedi, Alexander A. Kakaizada, Sofia Young, Jacob S. Kaur, Jasleen Wiese, Olivia Valdivia, Claudia Krishna, Saritha Weyer-Jamora, Christina Berger, Mitchel S. Weissman, Daniel H. Brang, David Hervey-Jumper, Shawn L. |
author_facet | Aabedi, Alexander A. Kakaizada, Sofia Young, Jacob S. Kaur, Jasleen Wiese, Olivia Valdivia, Claudia Krishna, Saritha Weyer-Jamora, Christina Berger, Mitchel S. Weissman, Daniel H. Brang, David Hervey-Jumper, Shawn L. |
author_sort | Aabedi, Alexander A. |
collection | PubMed |
description | Lexical retrieval requires selecting and retrieving the most appropriate word from the lexicon to express a desired concept. Few studies have probed lexical retrieval with tasks other than picture naming, and when non-picture naming lexical retrieval tasks have been applied, both convergent and divergent results emerged. The presence of a single construct for auditory and visual processes of lexical retrieval would influence cognitive rehabilitation strategies for patients with aphasia. In this study, we perform support vector regression lesion-symptom mapping using a brain tumor model to test the hypothesis that brain regions specifically involved in lexical retrieval from visual and auditory stimuli represent overlapping neural systems. We find that principal components analysis of language tasks revealed multicollinearity between picture naming, auditory naming, and a validated measure of word finding, implying the existence of redundant cognitive constructs. Nonparametric, multivariate lesion-symptom mapping across participants was used to model accuracies on each of the four language tasks. Lesions within overlapping clusters of 8,333 voxels and 21,512 voxels in the left lateral prefrontal cortex (PFC) were predictive of impaired picture naming and auditory naming, respectively. These data indicate a convergence of heteromodal lexical retrieval within the PFC. |
format | Online Article Text |
id | pubmed-7973515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79735152021-03-19 Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex Aabedi, Alexander A. Kakaizada, Sofia Young, Jacob S. Kaur, Jasleen Wiese, Olivia Valdivia, Claudia Krishna, Saritha Weyer-Jamora, Christina Berger, Mitchel S. Weissman, Daniel H. Brang, David Hervey-Jumper, Shawn L. Sci Rep Article Lexical retrieval requires selecting and retrieving the most appropriate word from the lexicon to express a desired concept. Few studies have probed lexical retrieval with tasks other than picture naming, and when non-picture naming lexical retrieval tasks have been applied, both convergent and divergent results emerged. The presence of a single construct for auditory and visual processes of lexical retrieval would influence cognitive rehabilitation strategies for patients with aphasia. In this study, we perform support vector regression lesion-symptom mapping using a brain tumor model to test the hypothesis that brain regions specifically involved in lexical retrieval from visual and auditory stimuli represent overlapping neural systems. We find that principal components analysis of language tasks revealed multicollinearity between picture naming, auditory naming, and a validated measure of word finding, implying the existence of redundant cognitive constructs. Nonparametric, multivariate lesion-symptom mapping across participants was used to model accuracies on each of the four language tasks. Lesions within overlapping clusters of 8,333 voxels and 21,512 voxels in the left lateral prefrontal cortex (PFC) were predictive of impaired picture naming and auditory naming, respectively. These data indicate a convergence of heteromodal lexical retrieval within the PFC. Nature Publishing Group UK 2021-03-18 /pmc/articles/PMC7973515/ /pubmed/33737672 http://dx.doi.org/10.1038/s41598-021-85802-5 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Aabedi, Alexander A. Kakaizada, Sofia Young, Jacob S. Kaur, Jasleen Wiese, Olivia Valdivia, Claudia Krishna, Saritha Weyer-Jamora, Christina Berger, Mitchel S. Weissman, Daniel H. Brang, David Hervey-Jumper, Shawn L. Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex |
title | Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex |
title_full | Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex |
title_fullStr | Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex |
title_full_unstemmed | Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex |
title_short | Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex |
title_sort | convergence of heteromodal lexical retrieval in the lateral prefrontal cortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973515/ https://www.ncbi.nlm.nih.gov/pubmed/33737672 http://dx.doi.org/10.1038/s41598-021-85802-5 |
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