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In vivo uptake of antisense oligonucleotide drugs predicted by ab initio quantum mechanical calculations

Liver and kidney uptake and antisense activity is studied for a series of Locked Nucleic Acid (LNA) oligonucleotides with fully stereo-defined, internucleoside linkages. These stereo-specific phosphorothioates are made with a newly developed synthesis method and are being analyzed both theoretically...

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Detalles Bibliográficos
Autores principales:	Hansen, Henrik Frydenlund, Albaek, Nanna, Hansen, Bo Rode, Shim, Irene, Bohr, Henrik, Koch, Troels
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973520/ https://www.ncbi.nlm.nih.gov/pubmed/33737567 http://dx.doi.org/10.1038/s41598-021-85453-6

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