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Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congen...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973552/ https://www.ncbi.nlm.nih.gov/pubmed/33737711 http://dx.doi.org/10.1038/s41598-021-85845-8 |
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author | Yoon, Jiyoung Lee, Junghwan Kim, Dae Sung Lee, Jin Wook Hong, Seung Wook Hwang, Ha Won Hwang, Sung Wook Park, Sang Hyoung Yang, Dong-Hoon Ye, Byong Duk Myung, Seung-Jae Jung, Hwoon-Yong Yang, Suk-Kyun Byeon, Jeong-Sik |
author_facet | Yoon, Jiyoung Lee, Junghwan Kim, Dae Sung Lee, Jin Wook Hong, Seung Wook Hwang, Ha Won Hwang, Sung Wook Park, Sang Hyoung Yang, Dong-Hoon Ye, Byong Duk Myung, Seung-Jae Jung, Hwoon-Yong Yang, Suk-Kyun Byeon, Jeong-Sik |
author_sort | Yoon, Jiyoung |
collection | PubMed |
description | We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congenital or acquired immunodeficiency syndrome, use of anti-cancer chemotherapeutic and immunosuppressive agents, and inflammatory bowel diseases. The mean age was 65.5 ± 11.8 years and 53 (61.6%) were male. Sixty-eight (79.1%) patients had comorbidities. Upper gastrointestinal-dominant, small bowel-dominant, and colon-dominant types were observed in 19, 7, and 60 patients, respectively. Endoscopic features could be classified into discrete ulcerative type with/without exudate and diffuse erythematous type with/without exudate. Antiviral treatment with ganciclovir was initiated in 51 patients (59.3%), 40 of whom improved and 1 improved after changing ganciclovir to foscarnet. Thirty-three patients (38.4%) improved without antiviral treatment. Surgery was necessary in two patients because of colon perforation before antiviral treatment. Another two patients underwent surgery because of sigmoid stricture and cecal perforation during antiviral treatment. Endoscopic type was not associated with clinical outcomes, such as surgery and death. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes. |
format | Online Article Text |
id | pubmed-7973552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79735522021-03-19 Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients Yoon, Jiyoung Lee, Junghwan Kim, Dae Sung Lee, Jin Wook Hong, Seung Wook Hwang, Ha Won Hwang, Sung Wook Park, Sang Hyoung Yang, Dong-Hoon Ye, Byong Duk Myung, Seung-Jae Jung, Hwoon-Yong Yang, Suk-Kyun Byeon, Jeong-Sik Sci Rep Article We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congenital or acquired immunodeficiency syndrome, use of anti-cancer chemotherapeutic and immunosuppressive agents, and inflammatory bowel diseases. The mean age was 65.5 ± 11.8 years and 53 (61.6%) were male. Sixty-eight (79.1%) patients had comorbidities. Upper gastrointestinal-dominant, small bowel-dominant, and colon-dominant types were observed in 19, 7, and 60 patients, respectively. Endoscopic features could be classified into discrete ulcerative type with/without exudate and diffuse erythematous type with/without exudate. Antiviral treatment with ganciclovir was initiated in 51 patients (59.3%), 40 of whom improved and 1 improved after changing ganciclovir to foscarnet. Thirty-three patients (38.4%) improved without antiviral treatment. Surgery was necessary in two patients because of colon perforation before antiviral treatment. Another two patients underwent surgery because of sigmoid stricture and cecal perforation during antiviral treatment. Endoscopic type was not associated with clinical outcomes, such as surgery and death. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes. Nature Publishing Group UK 2021-03-18 /pmc/articles/PMC7973552/ /pubmed/33737711 http://dx.doi.org/10.1038/s41598-021-85845-8 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yoon, Jiyoung Lee, Junghwan Kim, Dae Sung Lee, Jin Wook Hong, Seung Wook Hwang, Ha Won Hwang, Sung Wook Park, Sang Hyoung Yang, Dong-Hoon Ye, Byong Duk Myung, Seung-Jae Jung, Hwoon-Yong Yang, Suk-Kyun Byeon, Jeong-Sik Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
title | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
title_full | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
title_fullStr | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
title_full_unstemmed | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
title_short | Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
title_sort | endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973552/ https://www.ncbi.nlm.nih.gov/pubmed/33737711 http://dx.doi.org/10.1038/s41598-021-85845-8 |
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