Cargando…

The effects of the miR-21/SMAD7/TGF-β pathway on Th17 cell differentiation in COPD

Chronic obstructive pulmonary disease (COPD) is a complex disease with multiple etiologies, while smoking is the most established one. The present study investigated the modulation of T-helper 17 (Th17) cell differentiation by the miR-21/Smad7/TGF-β pathway, and their roles in COPD. Lung tissues wer...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Shengyang, Sun, Shenghua, Lu, Junjuan, Chen, Lili, Mei, Xiang, Li, Liqiu, Zeng, Zhengpeng, Zhong, Mubin, Xie, Lihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973755/ https://www.ncbi.nlm.nih.gov/pubmed/33739023 http://dx.doi.org/10.1038/s41598-021-85637-0

Ejemplares similares

A Novel Murine Chronic Obstructive Pulmonary Disease Model and the Pathogenic Role of MicroRNA-21
por: He, Shengyang, et al.
Publicado: (2018)

Characteristics and potential role of M2 macrophages in COPD
por: He, Shengyang, et al.
Publicado: (2017)

The inhibitor miR-21 regulates macrophage polarization in an experimental model of chronic obstructive pulmonary disease
por: Lu, JunJuan, et al.
Publicado: (2021)

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation
por: Loboda, Agnieszka, et al.
Publicado: (2016)

MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
por: Li, Qiong, et al.
Publicado: (2013)

TGF-β1 regulating miR-205/miR-195 expression affects the TGF-β signal pathway by respectively targeting SMAD2/SMAD7
por: Duan, Yingjun, et al.
Publicado: (2016)

The Regulation and Function of miR-21-FOXO3a-miR-34b/c Signaling in Breast Cancer
por: Liu, Xiangyan, et al.
Publicado: (2015)

Dasatinib ameliorates thioacetamide-induced liver fibrosis: modulation of miR-378 and miR-17 and their linked Wnt/β-catenin and TGF-β/smads pathways
por: Zaafan, Mai A., et al.
Publicado: (2021)

The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways
por: Abdelhamid, Amr M., et al.
Publicado: (2021)

MiR-208b/miR-21 Promotes the Progression of Cardiac Fibrosis Through the Activation of the TGF-β1/Smad-3 Signaling Pathway: An in vitro and in vivo Study
por: Zhang, Yifan, et al.
Publicado: (2022)

NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis
por: Tardif, Ginette, et al.
Publicado: (2013)

Radiation quality-dependence of bystander effect in unirradiated fibroblasts is associated with TGF-β1-Smad2 pathway and miR-21 in irradiated keratinocytes
por: Yin, Xiaoming, et al.
Publicado: (2015)

Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo
por: Yang, Fan, et al.
Publicado: (2017)

EPC-exosomal miR-26a-5p improves airway remodeling in COPD by inhibiting ferroptosis of bronchial epithelial cells via PTGS2/PGE2 signaling pathway
por: Liu, Caihong, et al.
Publicado: (2023)

Smad2-Dependent Downregulation of miR-30 Is Required for TGF-β-Induced Apoptosis in Podocytes
por: Shi, Shaolin, et al.
Publicado: (2013)

miR-127 accelerates myocardial failure by promoting TGF-β1/Smad3 signaling
por: Xu, Hainian, et al.
Publicado: (2019)

miR-1306 Mediates the Feedback Regulation of the TGF-β/SMAD Signaling Pathway in Granulosa Cells
por: Yang, Liu, et al.
Publicado: (2019)

miR-127 aggravates myocardial failure by promoting the TGF-β1/Smad3 signaling
por: Xu, Hainian, et al.
Publicado: (2018)

Hsa-miR-587 Regulates TGFβ/SMAD Signaling and Promotes Cell Cycle Progression
por: Jahangirimoez, Mahnaz, et al.
Publicado: (2020)

Mannan-Binding Lectin Regulates the Th17/Treg Axis Through JAK/STAT and TGF-β/SMAD Signaling Against Candida albicans Infection
por: Wang, Fanping, et al.
Publicado: (2022)

miR‐21‐5p/SMAD7 axis promotes the progress of lung cancer
por: Tang, Jinming, et al.
Publicado: (2021)

The Expression of TGF-β1, SMAD3, ILK and miRNA-21 in the Ectopic and Eutopic Endometrium of Women with Endometriosis
por: Zubrzycka, Anna, et al.
Publicado: (2023)

Th17 profile in COPD exacerbations
por: Ponce-Gallegos, Marco Antonio, et al.
Publicado: (2017)

Bioflavonoid Galangin Suppresses Hypertrophic Scar Formation by the TGF-β/Smad Signaling Pathway
por: Ru, Zha, et al.
Publicado: (2021)

Effect of TGF-β/smad signaling pathway blocking on expression profiles of miR-335, miR-150, miR-194, miR-27a, and miR-199a of hepatic stellate cells (HSCs)
por: Davoodian, Parivash, et al.
Publicado: (2017)

miR-4666-3p and miR-329 Synergistically Suppress the Stemness of Colorectal Cancer Cells via Targeting TGF-β/Smad Pathway
por: Ye, Jun, et al.
Publicado: (2019)

miR-211 alleviates ischaemia/reperfusion-induced kidney injury by targeting TGFβR2/TGF-β/SMAD3 pathway
por: Shang, Jinchun, et al.
Publicado: (2020)

WFDC21P promotes triple-negative breast cancer proliferation and migration through WFDC21P/miR-628/SMAD3 axis
por: Wei, Yu-Bo, et al.
Publicado: (2022)

MiR-17 and miR-93 Promote Tumor Progression by Targeting p21 in Patients with Chordoma
por: Dong, Wei, et al.
Publicado: (2021)

Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through the miR-663a/TGF-β1/Smad axis
por: Zhang, Yue, et al.
Publicado: (2022)

NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma
por: Wang, Hui, et al.
Publicado: (2015)

MiR-10a improves hepatic fibrosis by regulating the TGFβl/Smads signal transduction pathway
por: Zhou, Guangyao, et al.
Publicado: (2016)

miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling
por: Xu, Peng, et al.
Publicado: (2020)

Associations of Circulating MicroRNAs (miR-17, miR-21, and miR-150) and Chronic Kidney Disease in a Japanese Population
por: Fujii, Ryosuke, et al.
Publicado: (2020)

miR-183 modulated cell proliferation and apoptosis in ovarian cancer through the TGF-β/Smad4 signaling pathway
por: Zhou, Junhui, et al.
Publicado: (2019)

Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF-β/miR-195/Smad signaling pathway
por: Song, Li-Ying, et al.
Publicado: (2019)

Expression Profiling and Functional Characterization of miR-26a and miR-130a in Regulating Zhongwei Goat Hair Development via the TGF-β/SMAD Pathway
por: Ding, Yangyang, et al.
Publicado: (2020)

Upregulation of miR‐9 and miR‐193b over human Th17 cell differentiation
por: Shirani, Fahimeh, et al.
Publicado: (2020)

Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway
por: Zhang, Yan, et al.
Publicado: (2012)

TRIMming TGF-β signals in Th17 cells
por: Rapaport, Aaron S., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3kkrf5nph5lfgjpstatrcovd76