Cargando…

Assisting PNA transport through cystic fibrosis human airway epithelia with biodegradable hybrid lipid-polymer nanoparticles

Cystic fibrosis (CF) is characterized by an airway obstruction caused by a thick mucus due to a malfunctioning Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. The sticky mucus restricts drugs in reaching target cells limiting the efficiency of treatments. The development of new a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Comegna, Marika, Conte, Gemma, Falanga, Andrea Patrizia, Marzano, Maria, Cernera, Gustavo, Di Lullo, Antonella Miriam, Amato, Felice, Borbone, Nicola, D’Errico, Stefano, Ungaro, Francesca, d’Angelo, Ivana, Oliviero, Giorgia, Castaldo, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973768/ https://www.ncbi.nlm.nih.gov/pubmed/33737583 http://dx.doi.org/10.1038/s41598-021-85549-z

Ejemplares similares

Bioconjugation of a PNA Probe to Zinc Oxide Nanowires for Label-Free Sensing
por: Crisci, Teresa, et al.
Publicado: (2021)

PNA-Based Graphene Oxide/Porous Silicon Hybrid Biosensor: Towards a Label-Free Optical Assay for Brugada Syndrome
por: Moretta, Rosalba, et al.
Publicado: (2020)

Molecular Analysis of Prothrombotic Gene Variants in Venous Thrombosis: A Potential Role for Sex and Thrombotic Localization
por: Cernera, Gustavo, et al.
Publicado: (2020)

New G-Quadruplex-Forming Oligodeoxynucleotides Incorporating a Bifunctional Double-Ended Linker (DEL): Effects of DEL Size and ODNs Orientation on the Topology, Stability, and Molecularity of DEL-G-Quadruplexes
por: Marzano, Maria, et al.
Publicado: (2019)

Evaluation of an Analogue of the Marine ε-PLL Peptide as a Ligand of G-quadruplex DNA Structures
por: Marzano, Maria, et al.
Publicado: (2020)

TAS2R38 is a novel modifier gene in patients with cystic fibrosis
por: Castaldo, Alice, et al.
Publicado: (2020)

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca(2+)-Modulating Activity Isolated from Sea Urchin Eggs
por: D’Errico, Stefano, et al.
Publicado: (2019)

Peptide Nucleic Acids as miRNA Target Protectors for the Treatment of Cystic Fibrosis
por: Zarrilli, Federica, et al.
Publicado: (2017)

Lung Microbiome in Cystic Fibrosis
por: Scialo, Filippo, et al.
Publicado: (2021)

Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex
por: D’Errico, Stefano, et al.
Publicado: (2020)

Molecular Analysis of Prothrombotic Gene Variants in Patients with Acute Ischemic Stroke and with Transient Ischemic Attack
por: Cernera, Gustavo, et al.
Publicado: (2021)

Elexacaftor–Tezacaftor–Ivacaftor Therapy for Cystic Fibrosis Patients with The F508del/Unknown Genotype
por: Comegna, Marika, et al.
Publicado: (2021)

Exploitation of a Very Small Peptide Nucleic Acid as a New Inhibitor of miR-509-3p Involved in the Regulation of Cystic Fibrosis Disease-Gene Expression
por: Amato, Felice, et al.
Publicado: (2014)

3D Chitosan-Gallic Acid Complexes: Assessment of the Chemical and Biological Properties
por: Marzano, Maria, et al.
Publicado: (2022)

Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin
por: Greco, Francesca, et al.
Publicado: (2022)

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose
por: D’Errico, Stefano, et al.
Publicado: (2011)

Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
por: D’Errico, Stefano, et al.
Publicado: (2013)

A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue
por: D’Errico, Stefano, et al.
Publicado: (2012)

5-Amino-1-(2′,3′-O-isopropylidene-d-ribityl)-1H-imidazole-4-carboxamide: a crystal structure with Z′ = 4
por: Piccialli, Vincenzo, et al.
Publicado: (2017)

Impaired Ratio of Unsaturated to Saturated Non-Esterified Fatty Acids in Saliva from Patients with Cystic Fibrosis
por: Gelzo, Monica, et al.
Publicado: (2020)

Exploring a peptide nucleic acid-based antisense approach for CD5 targeting in chronic lymphocytic leukemia
por: Cesaro, Elena, et al.
Publicado: (2022)

NGS Gene Panel Analysis Revealed Novel Mutations in Patients with Rare Congenital Diarrheal Disorders
por: Esposito, Maria Valeria, et al.
Publicado: (2021)

Exploring the Relationship between G-Quadruplex Nucleic Acids and Plants: From Plant G-Quadruplex Function to Phytochemical G4 Ligands with Pharmaceutic Potential
por: Falanga, Andrea P., et al.
Publicado: (2022)

Prenatal Diagnosis of Cystic Fibrosis and Hemophilia: Incidental Findings and Weak Points
por: Comegna, Marika, et al.
Publicado: (2019)

Extensive CFTR Gene Analysis Revealed a Higher Occurrence of Cystic Fibrosis Transmembrane Regulator-Related Disorders (CFTR-RD) among CF Carriers
por: Esposito, Maria Valeria, et al.
Publicado: (2020)

S737F is a new CFTR mutation typical of patients originally from the Tuscany region in Italy
por: Terlizzi, Vito, et al.
Publicado: (2018)

Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era
por: Borbone, Nicola, et al.
Publicado: (2022)

Synthesis of mixed-sequence oligonucleotides on mesoporous silicon: chemical strategies and material stability
por: Terracciano, Monica, et al.
Publicado: (2014)

Two cases of microvillous inclusion disease caused by novel mutations in MYO5B gene
por: Comegna, Marika, et al.
Publicado: (2018)

Synthesis of cyclic N(1)-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells
por: Mahal, Ahmed, et al.
Publicado: (2015)

Age-Related Differences in the Expression of Most Relevant Mediators of SARS-CoV-2 Infection in Human Respiratory and Gastrointestinal Tract
por: Berni Canani, Roberto, et al.
Publicado: (2021)

Corrigendum: Age-Related Differences in the Expression of Most Relevant Mediators of SARS-CoV-2 Infection in Human Respiratory and Gastrointestinal Tract
por: Berni Canani, Roberto, et al.
Publicado: (2021)

Self‐Assembly of G‐Rich Oligonucleotides Incorporating a 3′–3′ Inversion of Polarity Site: A New Route Towards G‐Wire DNA Nanostructures
por: Oliviero, Giorgia, et al.
Publicado: (2017)

Design, Synthesis and Characterization of Novel Co-Polymers Decorated with Peptides for the Selective Nanoparticle Transport across the Cerebral Endothelium
por: Falanga, Andrea P., et al.
Publicado: (2018)

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs
por: D’Errico, Stefano, et al.
Publicado: (2018)

An "ex vivo model" contributing to the diagnosis and evaluation of new drugs in cystic fibrosis
por: Di Lullo, A.M., et al.
Publicado: (2017)

Fluorogenic PNA probes
por: Vilaivan, Tirayut
Publicado: (2018)

Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties
por: D’Errico, Stefano, et al.
Publicado: (2014)

CD, UV, and In Silico Insights on the Effect of 1,3-Bis(1′-uracilyl)-2-propanone on Serum Albumin Structure
por: Greco, Francesca, et al.
Publicado: (2022)

SARS-CoV-2 Subgenomic N (sgN) Transcripts in Oro-Nasopharyngeal Swabs Correlate with the Highest Viral Load, as Evaluated by Five Different Molecular Methods
por: Zollo, Massimo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ied8oiceq7v9mltvghvbkanqg2