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Suppressing the impact of the COVID-19 pandemic using controlled testing and isolation

The Corona virus disease has significantly affected lives of people around the world. Existing quarantine policies led to large-scale lock-downs because of the slow tracking of the infection paths, and indeed we see new waves of the disease. This can be solved by contact tracing combined with effici...

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Autores principales: Cohen, Kobi, Leshem, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973790/
https://www.ncbi.nlm.nih.gov/pubmed/33737580
http://dx.doi.org/10.1038/s41598-021-85458-1
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author Cohen, Kobi
Leshem, Amir
author_facet Cohen, Kobi
Leshem, Amir
author_sort Cohen, Kobi
collection PubMed
description The Corona virus disease has significantly affected lives of people around the world. Existing quarantine policies led to large-scale lock-downs because of the slow tracking of the infection paths, and indeed we see new waves of the disease. This can be solved by contact tracing combined with efficient testing policies. Since the number of daily tests is limited, it is crucial to exploit them efficiently to improve the outcome of contact tracing (technological or human-based epidemiological investigations). We develop a controlled testing framework to achieve this goal. The key is to test individuals with high probability of being infected to identify them before symptoms appear. These probabilities are updated based on contact tracing and test results. We demonstrate that the proposed method could reduce the quarantine and morbidity rates compared to existing methods by up to a 50%. The results clearly demonstrate the necessity of accelerating the epidemiological investigations by using technological contact tracing. Furthermore, proper use of the testing capacity using the proposed controlled testing methodology leads to significantly improved results under both small and large testing capacities. We also show that for small new outbreaks controlled testing can prevent the large spread of new waves. Author contributions statement: The authors contributed equally to this work, including conceptualization, analysis, methodology, software, and drafting the work.
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spelling pubmed-79737902021-03-19 Suppressing the impact of the COVID-19 pandemic using controlled testing and isolation Cohen, Kobi Leshem, Amir Sci Rep Article The Corona virus disease has significantly affected lives of people around the world. Existing quarantine policies led to large-scale lock-downs because of the slow tracking of the infection paths, and indeed we see new waves of the disease. This can be solved by contact tracing combined with efficient testing policies. Since the number of daily tests is limited, it is crucial to exploit them efficiently to improve the outcome of contact tracing (technological or human-based epidemiological investigations). We develop a controlled testing framework to achieve this goal. The key is to test individuals with high probability of being infected to identify them before symptoms appear. These probabilities are updated based on contact tracing and test results. We demonstrate that the proposed method could reduce the quarantine and morbidity rates compared to existing methods by up to a 50%. The results clearly demonstrate the necessity of accelerating the epidemiological investigations by using technological contact tracing. Furthermore, proper use of the testing capacity using the proposed controlled testing methodology leads to significantly improved results under both small and large testing capacities. We also show that for small new outbreaks controlled testing can prevent the large spread of new waves. Author contributions statement: The authors contributed equally to this work, including conceptualization, analysis, methodology, software, and drafting the work. Nature Publishing Group UK 2021-03-18 /pmc/articles/PMC7973790/ /pubmed/33737580 http://dx.doi.org/10.1038/s41598-021-85458-1 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cohen, Kobi
Leshem, Amir
Suppressing the impact of the COVID-19 pandemic using controlled testing and isolation
title Suppressing the impact of the COVID-19 pandemic using controlled testing and isolation
title_full Suppressing the impact of the COVID-19 pandemic using controlled testing and isolation
title_fullStr Suppressing the impact of the COVID-19 pandemic using controlled testing and isolation
title_full_unstemmed Suppressing the impact of the COVID-19 pandemic using controlled testing and isolation
title_short Suppressing the impact of the COVID-19 pandemic using controlled testing and isolation
title_sort suppressing the impact of the covid-19 pandemic using controlled testing and isolation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973790/
https://www.ncbi.nlm.nih.gov/pubmed/33737580
http://dx.doi.org/10.1038/s41598-021-85458-1
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