Sequential administration of anti-PD-1 and anti-Tim-3 combined with an SA-GM-CSF-anchored vaccine overcomes adaptive immune resistance to reject established bladder cancer

Program death receptor-1 (PD-1) and T-cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) play an important role in tumor immune evasion. PD-1 blockade could produce an effective anti-tumor effect but the response rate was low due to lacking of tumor infiltrating lymphocytes (TILs) and...

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Detalles Bibliográficos
Autores principales: Zhang, Xinji, Liu, Guang, Shi, Xianghua, Shi, Xiaojun, Li, Jinlong, Mo, Lijun, Gao, Jimin, Long, Zhaolin, Tan, Wanlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974521/
https://www.ncbi.nlm.nih.gov/pubmed/33753998
http://dx.doi.org/10.7150/jca.44769

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