Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack

Therapeutic vaccination regimens inducing clinically effective tumor-specific CD8(+) T lymphocyte (CTL) responses are an unmet medical need. We engineer two distantly related arenaviruses, Pichinde virus and lymphocytic choriomeningitis virus, for therapeutic cancer vaccination. In mice, life-replic...

Descripción completa

Detalles Bibliográficos
Autores principales: Bonilla, Weldy V., Kirchhammer, Nicole, Marx, Anna-Friederike, Kallert, Sandra M., Krzyzaniak, Magdalena A., Lu, Min, Darbre, Stéphanie, Schmidt, Sarah, Raguz, Josipa, Berka, Ursula, Vincenti, Ilena, Pauzuolis, Mindaugas, Kerber, Romy, Hoepner, Sabine, Günther, Stephan, Magnus, Carsten, Merkler, Doron, Orlinger, Klaus K., Zippelius, Alfred, Pinschewer, Daniel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974551/
https://www.ncbi.nlm.nih.gov/pubmed/33763654
http://dx.doi.org/10.1016/j.xcrm.2021.100209

Ejemplares similares

Ejemplares similares