Metabolites of shikimate and tryptophan pathways in coronavirus disease (COVID-19)

Both Alzheimer disease (AD) and COVID-19 are age-dependent diseases with a high prevalence of obesity and diabetes. Proteomic and metabolomic profiling of sera from COVID-19 patients is discussed in this chapter. Some shikimate pathway-tryptophan metabolites are altered in the blood sera of severe COVID-19 versus healthy controls. Metabolites of bile acids increased in the sera of COVID-19 patients. In the serum metabolomics of severe COVID-19 patients versus healthy, serotonin was lower, −1.72 fold, and tryptophan was lower, −0.567 fold. The complete autopsy examinations may indicate that manifestations in different organs of COVID-19 patients can be caused by chronic and acute toxicity. This suggestion is consistent with data on serum metabolic profiling of COVID-19 patients.