An updated meta-analysis: repetitive transcranial magnetic stimulation for treating tinnitus

OBJECTIVE: To undertake an updated meta-analysis to obtain more evidence from randomized controlled trials (RCTs) to assess the effect of repetitive transcranial magnetic stimulation (rTMS) for the treatment of tinnitus. METHODS: PubMed®, Embase®, Web of Science, Cochrane Database of Systematic Reviews, CBM, CNKI and Wanfang were searched for RCTs from inception up to March 2020. Studies meeting the eligibility criteria were included in the meta-analysis. The mean difference was calculated and the effect size was evaluated using a Z test. RESULTS: The analysis included 12 randomized sham-controlled clinical trials with a total of 717 participants. Active rTMS was superior to sham rTMS in terms of the short-term and long-term effects (6 months) on the tinnitus handicap inventory scores, but an immediate effect was not significant. There was no significant immediate effect on the tinnitus questionnaire (TQ) and Beck depression inventory (BDI) scores. CONCLUSIONS: This meta-analysis demonstrated that rTMS improved tinnitus-related symptoms, but the TQ and BDI scores demonstrated little immediate benefit. Future research should be undertaken on large samples in multi-centre settings with longer follow-up durations.