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Role and application of stem cells in dental regeneration: A comprehensive overview

Recently, a growing attention has been observed toward potential advantages of stem cell (SC)-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now considered excellent candidates for tissue replacement therapies and tissue engineering. Autologous MSCs importantly...

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Autores principales: Soudi, Armin, Yazdanian, Mohsen, Ranjbar, Reza, Tebyanian, Hamid, Yazdanian, Alireza, Tahmasebi, Elahe, Keshvad, Ali, Seifalian, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975587/
https://www.ncbi.nlm.nih.gov/pubmed/33746673
http://dx.doi.org/10.17179/excli2021-3335
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author Soudi, Armin
Yazdanian, Mohsen
Ranjbar, Reza
Tebyanian, Hamid
Yazdanian, Alireza
Tahmasebi, Elahe
Keshvad, Ali
Seifalian, Alexander
author_facet Soudi, Armin
Yazdanian, Mohsen
Ranjbar, Reza
Tebyanian, Hamid
Yazdanian, Alireza
Tahmasebi, Elahe
Keshvad, Ali
Seifalian, Alexander
author_sort Soudi, Armin
collection PubMed
description Recently, a growing attention has been observed toward potential advantages of stem cell (SC)-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now considered excellent candidates for tissue replacement therapies and tissue engineering. Autologous MSCs importantly contribute to the state-of-the-art clinical strategies for SC-based alveolar bone regeneration. The donor cells and immune cells play a prominent role in determining the clinical success of MSCs therapy. In line with the promising future that stem cell therapy has shown for tissue engineering applications, dental stem cells have also attracted the attention of the relevant researchers in recent years. The current literature review aims to survey the variety and extension of SC-application in tissue-regenerative dentistry. In this regard, the relevant English written literature was searched using keywords: “tissue engineering”, “stem cells”, “dental stem cells”, and “dentistry strategies”. According to the available database, SCs application has become increasingly widespread because of its accessibility, plasticity, and high proliferative ability. Among the growing recognized niches and tissues containing higher SCs, dental tissues are evidenced to be rich sources of MSCs. According to the literature, dental SCs are mostly present in the dental pulp, periodontal ligament, and dental follicle tissues. In this regard, the present review has described the recent findings on the potential of dental stem cells to be used in tissue regeneration.
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spelling pubmed-79755872021-03-19 Role and application of stem cells in dental regeneration: A comprehensive overview Soudi, Armin Yazdanian, Mohsen Ranjbar, Reza Tebyanian, Hamid Yazdanian, Alireza Tahmasebi, Elahe Keshvad, Ali Seifalian, Alexander EXCLI J Review Article Recently, a growing attention has been observed toward potential advantages of stem cell (SC)-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now considered excellent candidates for tissue replacement therapies and tissue engineering. Autologous MSCs importantly contribute to the state-of-the-art clinical strategies for SC-based alveolar bone regeneration. The donor cells and immune cells play a prominent role in determining the clinical success of MSCs therapy. In line with the promising future that stem cell therapy has shown for tissue engineering applications, dental stem cells have also attracted the attention of the relevant researchers in recent years. The current literature review aims to survey the variety and extension of SC-application in tissue-regenerative dentistry. In this regard, the relevant English written literature was searched using keywords: “tissue engineering”, “stem cells”, “dental stem cells”, and “dentistry strategies”. According to the available database, SCs application has become increasingly widespread because of its accessibility, plasticity, and high proliferative ability. Among the growing recognized niches and tissues containing higher SCs, dental tissues are evidenced to be rich sources of MSCs. According to the literature, dental SCs are mostly present in the dental pulp, periodontal ligament, and dental follicle tissues. In this regard, the present review has described the recent findings on the potential of dental stem cells to be used in tissue regeneration. Leibniz Research Centre for Working Environment and Human Factors 2021-02-22 /pmc/articles/PMC7975587/ /pubmed/33746673 http://dx.doi.org/10.17179/excli2021-3335 Text en Copyright © 2021 Soudi et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Review Article
Soudi, Armin
Yazdanian, Mohsen
Ranjbar, Reza
Tebyanian, Hamid
Yazdanian, Alireza
Tahmasebi, Elahe
Keshvad, Ali
Seifalian, Alexander
Role and application of stem cells in dental regeneration: A comprehensive overview
title Role and application of stem cells in dental regeneration: A comprehensive overview
title_full Role and application of stem cells in dental regeneration: A comprehensive overview
title_fullStr Role and application of stem cells in dental regeneration: A comprehensive overview
title_full_unstemmed Role and application of stem cells in dental regeneration: A comprehensive overview
title_short Role and application of stem cells in dental regeneration: A comprehensive overview
title_sort role and application of stem cells in dental regeneration: a comprehensive overview
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975587/
https://www.ncbi.nlm.nih.gov/pubmed/33746673
http://dx.doi.org/10.17179/excli2021-3335
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