Molecular pathways in the development of HPV-induced cervical cancer

Recently, human papillomavirus (HPV) has gained considerable attention in cervical cancer research studies. It is one of the most important sexually transmitted diseases that can affect 160 to 289 out of 10000 persons every year. Due to the infectious nature of this virus, HPV can be considered a se...

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Detalles Bibliográficos
Autores principales: Rasi Bonab, Farnaz, Baghbanzadeh, Amir, Ghaseminia, Moslem, Bolandi, Nadia, Mokhtarzadeh, Ahad, Amini, Mohammad, Dadashzadeh, Kianoosh, Hajiasgharzadeh, Khalil, Baradaran, Behzad, Bannazadeh Baghi, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975633/
https://www.ncbi.nlm.nih.gov/pubmed/33746665
http://dx.doi.org/10.17179/excli2021-3365
Descripción
Sumario:Recently, human papillomavirus (HPV) has gained considerable attention in cervical cancer research studies. It is one of the most important sexually transmitted diseases that can affect 160 to 289 out of 10000 persons every year. Due to the infectious nature of this virus, HPV can be considered a serious threat. The knowledge of viral structure, especially for viral oncoproteins like E6, E7, and their role in causing cancer is very important. This virus has different paths (PI3K/Akt, Wnt/β-catenin, ERK/MAPK, and JAK/STAT) that are involved in the transmission of signaling paths through active molecules like MEK (pMEK), ERK (pERK), and Akt (pAkt). It's eventually through these paths that cancer is developed. Precise knowledge of these paths and their signals give us the prognosis to adopt appropriate goals for prevention and control of these series of cancer.

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