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Food Dependent Exercise-Induced Anaphylaxis. Can we trust the oral food challenge with exercise and acetylsalicylic acid?

Food-dependent exercise-induced anaphylaxis (FDEIA) is an IgE-mediated allergy resulting from the combination of the ingestion of an offending food and physical exercise. According literature, oral food challenge (OFC) followed by physical exercise (OFCPE) should be considered the diagnostic gold st...

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Detalles Bibliográficos
Autores principales: Miceli Sopo, Stefano, Gelsomino, Mariannita, Del Vescovo, Ester, Bersani, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975926/
https://www.ncbi.nlm.nih.gov/pubmed/33682838
http://dx.doi.org/10.23750/abm.v92i1.10093
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author Miceli Sopo, Stefano
Gelsomino, Mariannita
Del Vescovo, Ester
Bersani, Giulia
author_facet Miceli Sopo, Stefano
Gelsomino, Mariannita
Del Vescovo, Ester
Bersani, Giulia
author_sort Miceli Sopo, Stefano
collection PubMed
description Food-dependent exercise-induced anaphylaxis (FDEIA) is an IgE-mediated allergy resulting from the combination of the ingestion of an offending food and physical exercise. According literature, oral food challenge (OFC) followed by physical exercise (OFCPE) should be considered the diagnostic gold standard. In the absence of adverse reactions, other cofactors should be added (e.g. acetylsalicylic acid, alcohol in adulthood), one at a time. But many other factors increase patient’s reactivity. This could reduce the sensitivity of the OFCPE and, consequently, make instructions for patients less reliable. On the other hand, the addition of cofactors not reported by the patient may reduce test specificity. With the help of two exemplary stories, that present opposite outcomes, diagnostic difficulties of FDEIA are discussed.
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spelling pubmed-79759262021-03-24 Food Dependent Exercise-Induced Anaphylaxis. Can we trust the oral food challenge with exercise and acetylsalicylic acid? Miceli Sopo, Stefano Gelsomino, Mariannita Del Vescovo, Ester Bersani, Giulia Acta Biomed Focus on Food-dependent exercise-induced anaphylaxis (FDEIA) is an IgE-mediated allergy resulting from the combination of the ingestion of an offending food and physical exercise. According literature, oral food challenge (OFC) followed by physical exercise (OFCPE) should be considered the diagnostic gold standard. In the absence of adverse reactions, other cofactors should be added (e.g. acetylsalicylic acid, alcohol in adulthood), one at a time. But many other factors increase patient’s reactivity. This could reduce the sensitivity of the OFCPE and, consequently, make instructions for patients less reliable. On the other hand, the addition of cofactors not reported by the patient may reduce test specificity. With the help of two exemplary stories, that present opposite outcomes, diagnostic difficulties of FDEIA are discussed. Mattioli 1885 2021 2020-12-22 /pmc/articles/PMC7975926/ /pubmed/33682838 http://dx.doi.org/10.23750/abm.v92i1.10093 Text en Copyright: © 2020 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Focus on
Miceli Sopo, Stefano
Gelsomino, Mariannita
Del Vescovo, Ester
Bersani, Giulia
Food Dependent Exercise-Induced Anaphylaxis. Can we trust the oral food challenge with exercise and acetylsalicylic acid?
title Food Dependent Exercise-Induced Anaphylaxis. Can we trust the oral food challenge with exercise and acetylsalicylic acid?
title_full Food Dependent Exercise-Induced Anaphylaxis. Can we trust the oral food challenge with exercise and acetylsalicylic acid?
title_fullStr Food Dependent Exercise-Induced Anaphylaxis. Can we trust the oral food challenge with exercise and acetylsalicylic acid?
title_full_unstemmed Food Dependent Exercise-Induced Anaphylaxis. Can we trust the oral food challenge with exercise and acetylsalicylic acid?
title_short Food Dependent Exercise-Induced Anaphylaxis. Can we trust the oral food challenge with exercise and acetylsalicylic acid?
title_sort food dependent exercise-induced anaphylaxis. can we trust the oral food challenge with exercise and acetylsalicylic acid?
topic Focus on
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975926/
https://www.ncbi.nlm.nih.gov/pubmed/33682838
http://dx.doi.org/10.23750/abm.v92i1.10093
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