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The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study

Although it is clear that infertility leads to heightened stress for patients, the impact of depressed mood and anxiety on treatment outcome is inconsistently reported. The aim of this study was to evaluate the effect of stress, depression and anxiety on in vitro fertilization (IVF) outcomes in Kaza...

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Autores principales: Bapayeva, Gauri, Aimagambetova, Gulzhanat, Issanov, Alpamys, Terzic, Sanja, Ukybassova, Talshyn, Aldiyarova, Aidana, Utepova, Gulnara, Daribay, Zhanibek, Bekbossinova, Gulnara, Balykov, Askhat, Laganà, Antonio Simone, Terzic, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975982/
https://www.ncbi.nlm.nih.gov/pubmed/33804325
http://dx.doi.org/10.3390/jcm10050937
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author Bapayeva, Gauri
Aimagambetova, Gulzhanat
Issanov, Alpamys
Terzic, Sanja
Ukybassova, Talshyn
Aldiyarova, Aidana
Utepova, Gulnara
Daribay, Zhanibek
Bekbossinova, Gulnara
Balykov, Askhat
Laganà, Antonio Simone
Terzic, Milan
author_facet Bapayeva, Gauri
Aimagambetova, Gulzhanat
Issanov, Alpamys
Terzic, Sanja
Ukybassova, Talshyn
Aldiyarova, Aidana
Utepova, Gulnara
Daribay, Zhanibek
Bekbossinova, Gulnara
Balykov, Askhat
Laganà, Antonio Simone
Terzic, Milan
author_sort Bapayeva, Gauri
collection PubMed
description Although it is clear that infertility leads to heightened stress for patients, the impact of depressed mood and anxiety on treatment outcome is inconsistently reported. The aim of this study was to evaluate the effect of stress, depression and anxiety on in vitro fertilization (IVF) outcomes in Kazakhstani public assisted reproductive technology (ART) clinics. The prospective cohort study was performed between June 2019 and September 2020 using questionnaires to assess psychological stress, depressed mood and anxiety in women referred to IVF clinics in two public clinical centers in Kazakhstan, Nur-Sultan and Aktobe. Our study sample comprised 142 women with the average age of 33.9 ± 4.9 years, and infertility duration 6.0 ± 3.5 years. More than half of respondents had Center for Epidemiological Studies Depression Scale (CES-D) scores higher than 16, indicating their risk of developing clinical depression. Ninety-one percent of women from Aktobe city were at risk for clinical depression (p < 0.001). Aktobe city respondents had higher stress subscale scores and anxiety scale scores (p < 0.001) than Nur-Sultan respondents. Statistical analysis showed that IVF outcome was not significantly associated with depression and stress, while the higher anxiety scale scores were negatively associated with clinical pregnancy after IVF.
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spelling pubmed-79759822021-03-20 The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study Bapayeva, Gauri Aimagambetova, Gulzhanat Issanov, Alpamys Terzic, Sanja Ukybassova, Talshyn Aldiyarova, Aidana Utepova, Gulnara Daribay, Zhanibek Bekbossinova, Gulnara Balykov, Askhat Laganà, Antonio Simone Terzic, Milan J Clin Med Article Although it is clear that infertility leads to heightened stress for patients, the impact of depressed mood and anxiety on treatment outcome is inconsistently reported. The aim of this study was to evaluate the effect of stress, depression and anxiety on in vitro fertilization (IVF) outcomes in Kazakhstani public assisted reproductive technology (ART) clinics. The prospective cohort study was performed between June 2019 and September 2020 using questionnaires to assess psychological stress, depressed mood and anxiety in women referred to IVF clinics in two public clinical centers in Kazakhstan, Nur-Sultan and Aktobe. Our study sample comprised 142 women with the average age of 33.9 ± 4.9 years, and infertility duration 6.0 ± 3.5 years. More than half of respondents had Center for Epidemiological Studies Depression Scale (CES-D) scores higher than 16, indicating their risk of developing clinical depression. Ninety-one percent of women from Aktobe city were at risk for clinical depression (p < 0.001). Aktobe city respondents had higher stress subscale scores and anxiety scale scores (p < 0.001) than Nur-Sultan respondents. Statistical analysis showed that IVF outcome was not significantly associated with depression and stress, while the higher anxiety scale scores were negatively associated with clinical pregnancy after IVF. MDPI 2021-03-01 /pmc/articles/PMC7975982/ /pubmed/33804325 http://dx.doi.org/10.3390/jcm10050937 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bapayeva, Gauri
Aimagambetova, Gulzhanat
Issanov, Alpamys
Terzic, Sanja
Ukybassova, Talshyn
Aldiyarova, Aidana
Utepova, Gulnara
Daribay, Zhanibek
Bekbossinova, Gulnara
Balykov, Askhat
Laganà, Antonio Simone
Terzic, Milan
The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study
title The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study
title_full The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study
title_fullStr The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study
title_full_unstemmed The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study
title_short The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study
title_sort effect of stress, anxiety and depression on in vitro fertilization outcome in kazakhstani public clinical setting: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7975982/
https://www.ncbi.nlm.nih.gov/pubmed/33804325
http://dx.doi.org/10.3390/jcm10050937
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