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Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19
We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into airborne nuclei’s infectivity and viral load distribution during the COVID-19 pandemic. The salt-water solution containing particles at reported viral loads is acoustically trapped in a contactless...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976039/ https://www.ncbi.nlm.nih.gov/pubmed/33746480 http://dx.doi.org/10.1063/5.0037360 |
Sumario: | We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into airborne nuclei’s infectivity and viral load distribution during the COVID-19 pandemic. The salt-water solution containing particles at reported viral loads is acoustically trapped in a contactless environment to emulate the drying, flow, and precipitation dynamics of real airborne droplets. Similar experiments validate observations with the surrogate fluid with samples of human saliva samples from a healthy subject. A unique feature emerges regarding the final crystallite dimension; it is always 20%–30% of the initial droplet diameter for different sizes and ambient conditions. Airborne-precipitates nearly enclose the viral load within its bulk while the substrate precipitates exhibit a high percentage (∼80–90%) of exposed virions (depending on the surface). This work demonstrates the leveraging of an inert nano-colloidal system to gain insights into an equivalent biological system. |
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