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Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19

We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into airborne nuclei’s infectivity and viral load distribution during the COVID-19 pandemic. The salt-water solution containing particles at reported viral loads is acoustically trapped in a contactless...

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Autores principales: Basu, Saptarshi, Kabi, Prasenjit, Chaudhuri, Swetaprovo, Saha, Abhishek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976039/
https://www.ncbi.nlm.nih.gov/pubmed/33746480
http://dx.doi.org/10.1063/5.0037360
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author Basu, Saptarshi
Kabi, Prasenjit
Chaudhuri, Swetaprovo
Saha, Abhishek
author_facet Basu, Saptarshi
Kabi, Prasenjit
Chaudhuri, Swetaprovo
Saha, Abhishek
author_sort Basu, Saptarshi
collection PubMed
description We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into airborne nuclei’s infectivity and viral load distribution during the COVID-19 pandemic. The salt-water solution containing particles at reported viral loads is acoustically trapped in a contactless environment to emulate the drying, flow, and precipitation dynamics of real airborne droplets. Similar experiments validate observations with the surrogate fluid with samples of human saliva samples from a healthy subject. A unique feature emerges regarding the final crystallite dimension; it is always 20%–30% of the initial droplet diameter for different sizes and ambient conditions. Airborne-precipitates nearly enclose the viral load within its bulk while the substrate precipitates exhibit a high percentage (∼80–90%) of exposed virions (depending on the surface). This work demonstrates the leveraging of an inert nano-colloidal system to gain insights into an equivalent biological system.
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spelling pubmed-79760392021-03-19 Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19 Basu, Saptarshi Kabi, Prasenjit Chaudhuri, Swetaprovo Saha, Abhishek Phys Fluids (1994) ARTICLES We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into airborne nuclei’s infectivity and viral load distribution during the COVID-19 pandemic. The salt-water solution containing particles at reported viral loads is acoustically trapped in a contactless environment to emulate the drying, flow, and precipitation dynamics of real airborne droplets. Similar experiments validate observations with the surrogate fluid with samples of human saliva samples from a healthy subject. A unique feature emerges regarding the final crystallite dimension; it is always 20%–30% of the initial droplet diameter for different sizes and ambient conditions. Airborne-precipitates nearly enclose the viral load within its bulk while the substrate precipitates exhibit a high percentage (∼80–90%) of exposed virions (depending on the surface). This work demonstrates the leveraging of an inert nano-colloidal system to gain insights into an equivalent biological system. AIP Publishing LLC 2020-12-01 2020-12-29 /pmc/articles/PMC7976039/ /pubmed/33746480 http://dx.doi.org/10.1063/5.0037360 Text en © 2020 Author(s) Published under license by AIP Publishing. 1070-6631/2020/32(12)/123317/8/$30.00 All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle ARTICLES
Basu, Saptarshi
Kabi, Prasenjit
Chaudhuri, Swetaprovo
Saha, Abhishek
Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19
title Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19
title_full Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19
title_fullStr Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19
title_full_unstemmed Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19
title_short Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19
title_sort insights on drying and precipitation dynamics of respiratory droplets from the perspective of covid-19
topic ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976039/
https://www.ncbi.nlm.nih.gov/pubmed/33746480
http://dx.doi.org/10.1063/5.0037360
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