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Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19
We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into airborne nuclei’s infectivity and viral load distribution during the COVID-19 pandemic. The salt-water solution containing particles at reported viral loads is acoustically trapped in a contactless...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976039/ https://www.ncbi.nlm.nih.gov/pubmed/33746480 http://dx.doi.org/10.1063/5.0037360 |
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author | Basu, Saptarshi Kabi, Prasenjit Chaudhuri, Swetaprovo Saha, Abhishek |
author_facet | Basu, Saptarshi Kabi, Prasenjit Chaudhuri, Swetaprovo Saha, Abhishek |
author_sort | Basu, Saptarshi |
collection | PubMed |
description | We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into airborne nuclei’s infectivity and viral load distribution during the COVID-19 pandemic. The salt-water solution containing particles at reported viral loads is acoustically trapped in a contactless environment to emulate the drying, flow, and precipitation dynamics of real airborne droplets. Similar experiments validate observations with the surrogate fluid with samples of human saliva samples from a healthy subject. A unique feature emerges regarding the final crystallite dimension; it is always 20%–30% of the initial droplet diameter for different sizes and ambient conditions. Airborne-precipitates nearly enclose the viral load within its bulk while the substrate precipitates exhibit a high percentage (∼80–90%) of exposed virions (depending on the surface). This work demonstrates the leveraging of an inert nano-colloidal system to gain insights into an equivalent biological system. |
format | Online Article Text |
id | pubmed-7976039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-79760392021-03-19 Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19 Basu, Saptarshi Kabi, Prasenjit Chaudhuri, Swetaprovo Saha, Abhishek Phys Fluids (1994) ARTICLES We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into airborne nuclei’s infectivity and viral load distribution during the COVID-19 pandemic. The salt-water solution containing particles at reported viral loads is acoustically trapped in a contactless environment to emulate the drying, flow, and precipitation dynamics of real airborne droplets. Similar experiments validate observations with the surrogate fluid with samples of human saliva samples from a healthy subject. A unique feature emerges regarding the final crystallite dimension; it is always 20%–30% of the initial droplet diameter for different sizes and ambient conditions. Airborne-precipitates nearly enclose the viral load within its bulk while the substrate precipitates exhibit a high percentage (∼80–90%) of exposed virions (depending on the surface). This work demonstrates the leveraging of an inert nano-colloidal system to gain insights into an equivalent biological system. AIP Publishing LLC 2020-12-01 2020-12-29 /pmc/articles/PMC7976039/ /pubmed/33746480 http://dx.doi.org/10.1063/5.0037360 Text en © 2020 Author(s) Published under license by AIP Publishing. 1070-6631/2020/32(12)/123317/8/$30.00 All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | ARTICLES Basu, Saptarshi Kabi, Prasenjit Chaudhuri, Swetaprovo Saha, Abhishek Insights on drying and precipitation dynamics of respiratory droplets from the perspective of COVID-19 |
title | Insights on drying and precipitation dynamics of respiratory droplets from
the perspective of COVID-19 |
title_full | Insights on drying and precipitation dynamics of respiratory droplets from
the perspective of COVID-19 |
title_fullStr | Insights on drying and precipitation dynamics of respiratory droplets from
the perspective of COVID-19 |
title_full_unstemmed | Insights on drying and precipitation dynamics of respiratory droplets from
the perspective of COVID-19 |
title_short | Insights on drying and precipitation dynamics of respiratory droplets from
the perspective of COVID-19 |
title_sort | insights on drying and precipitation dynamics of respiratory droplets from
the perspective of covid-19 |
topic | ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976039/ https://www.ncbi.nlm.nih.gov/pubmed/33746480 http://dx.doi.org/10.1063/5.0037360 |
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