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Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February
The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% conf...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976383/ https://www.ncbi.nlm.nih.gov/pubmed/33739254 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.11.2100256 |
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| author | Grint, Daniel J Wing, Kevin Williamson, Elizabeth McDonald, Helen I Bhaskaran, Krishnan Evans, David Evans, Stephen JW Walker, Alex J Hickman, George Nightingale, Emily Schultze, Anna Rentsch, Christopher T Bates, Chris Cockburn, Jonathan Curtis, Helen J Morton, Caroline E Bacon, Sebastian Davy, Simon Wong, Angel YS Mehrkar, Amir Tomlinson, Laurie Douglas, Ian J Mathur, Rohini Blomquist, Paula MacKenna, Brian Ingelsby, Peter Croker, Richard Parry, John Hester, Frank Harper, Sam DeVito, Nicholas J Hulme, Will Tazare, John Goldacre, Ben Smeeth, Liam Eggo, Rosalind M |
| author_facet | Grint, Daniel J Wing, Kevin Williamson, Elizabeth McDonald, Helen I Bhaskaran, Krishnan Evans, David Evans, Stephen JW Walker, Alex J Hickman, George Nightingale, Emily Schultze, Anna Rentsch, Christopher T Bates, Chris Cockburn, Jonathan Curtis, Helen J Morton, Caroline E Bacon, Sebastian Davy, Simon Wong, Angel YS Mehrkar, Amir Tomlinson, Laurie Douglas, Ian J Mathur, Rohini Blomquist, Paula MacKenna, Brian Ingelsby, Peter Croker, Richard Parry, John Hester, Frank Harper, Sam DeVito, Nicholas J Hulme, Will Tazare, John Goldacre, Ben Smeeth, Liam Eggo, Rosalind M |
| author_sort | Grint, Daniel J |
| collection | PubMed |
| description | The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34–2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date. |
| format | Online Article Text |
| id | pubmed-7976383 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-79763832021-03-24 Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February Grint, Daniel J Wing, Kevin Williamson, Elizabeth McDonald, Helen I Bhaskaran, Krishnan Evans, David Evans, Stephen JW Walker, Alex J Hickman, George Nightingale, Emily Schultze, Anna Rentsch, Christopher T Bates, Chris Cockburn, Jonathan Curtis, Helen J Morton, Caroline E Bacon, Sebastian Davy, Simon Wong, Angel YS Mehrkar, Amir Tomlinson, Laurie Douglas, Ian J Mathur, Rohini Blomquist, Paula MacKenna, Brian Ingelsby, Peter Croker, Richard Parry, John Hester, Frank Harper, Sam DeVito, Nicholas J Hulme, Will Tazare, John Goldacre, Ben Smeeth, Liam Eggo, Rosalind M Euro Surveill Rapid Communication The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34–2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date. European Centre for Disease Prevention and Control (ECDC) 2021-03-18 /pmc/articles/PMC7976383/ /pubmed/33739254 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.11.2100256 Text en This article is copyright of the authors or their affiliated institutions, 2021. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Rapid Communication Grint, Daniel J Wing, Kevin Williamson, Elizabeth McDonald, Helen I Bhaskaran, Krishnan Evans, David Evans, Stephen JW Walker, Alex J Hickman, George Nightingale, Emily Schultze, Anna Rentsch, Christopher T Bates, Chris Cockburn, Jonathan Curtis, Helen J Morton, Caroline E Bacon, Sebastian Davy, Simon Wong, Angel YS Mehrkar, Amir Tomlinson, Laurie Douglas, Ian J Mathur, Rohini Blomquist, Paula MacKenna, Brian Ingelsby, Peter Croker, Richard Parry, John Hester, Frank Harper, Sam DeVito, Nicholas J Hulme, Will Tazare, John Goldacre, Ben Smeeth, Liam Eggo, Rosalind M Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February |
| title | Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February |
| title_full | Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February |
| title_fullStr | Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February |
| title_full_unstemmed | Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February |
| title_short | Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February |
| title_sort | case fatality risk of the sars-cov-2 variant of concern b.1.1.7 in england, 16 november to 5 february |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976383/ https://www.ncbi.nlm.nih.gov/pubmed/33739254 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.11.2100256 |
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