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Investigation of clinicopathological characters and gene expression features in colorectal signet-ring cell carcinoma utilizing CMS classification
Signet ring cell carcinoma (SRCC) is a rare pathological type of colorectal cancer, of which the clinicopathological features and genetic background have not yet been fully investigated. Previous research has focused on the optimization of colorectal cancer treatment utilizing consensus molecular su...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976453/ https://www.ncbi.nlm.nih.gov/pubmed/33767867 http://dx.doi.org/10.3892/mco.2021.2260 |
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author | Tajiri, Kensuke Sudo, Tomoya Ishi, Kazuo Kawahara, Akihiko Nagasu, Sachiko Shimomura, Susumu Yuge, Kotaro Katagiri, Mitsuhiro Yomoda, Takato Fujiyoshi, Kenji Kenichi, Koshi Ohchi, Takafumi Yoshida, Takefumi Mizobe, Tomoaki Fujita, Fumihiko Akiba, Jun Akagi, Yoshito |
author_facet | Tajiri, Kensuke Sudo, Tomoya Ishi, Kazuo Kawahara, Akihiko Nagasu, Sachiko Shimomura, Susumu Yuge, Kotaro Katagiri, Mitsuhiro Yomoda, Takato Fujiyoshi, Kenji Kenichi, Koshi Ohchi, Takafumi Yoshida, Takefumi Mizobe, Tomoaki Fujita, Fumihiko Akiba, Jun Akagi, Yoshito |
author_sort | Tajiri, Kensuke |
collection | PubMed |
description | Signet ring cell carcinoma (SRCC) is a rare pathological type of colorectal cancer, of which the clinicopathological features and genetic background have not yet been fully investigated. Previous research has focused on the optimization of colorectal cancer treatment utilizing consensus molecular subtyping (CMS). However, it is not known what type of CMS would be designated to SRCC treatment. In the current study, of 1,350 patients diagnosed with colorectal cancer who underwent surgery, 14 were diagnosed with SRCC. The case-control cohort that fit the clinical background of the SRCC case was constructed. Statistical comparison between the SRCC group and the case-control cohort was performed among clinicopathological variables. SRCC and well to moderately adenocarcinoma case mRNA were submitted to microarray analysis and CMS analysis. Compared with the case-control cohort, the SRCC group was located more in the right-sided colon, the lymphatic invasion was more severe and the peritoneal dissemination was more frequent. The cancer-specific survival and the progression-free survival were significantly worse in the SRCC group compared with the case-control cohort. Microarray and CMS analysis identified that one SRCC case was significantly well assigned in the CMS 4 group and the other case was assigned in the CMS 1 group. Gene set analysis revealed the upregulation of EMT related genes and the downregulation of fatty acid, glycolysis, differentiation, MYC, HNF4A, DNA repair genes. In conclusion, the clinical characteristics of SRCC are severe but there is a possibility of the presence of different phenotypes according to CMS analysis. |
format | Online Article Text |
id | pubmed-7976453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-79764532021-03-24 Investigation of clinicopathological characters and gene expression features in colorectal signet-ring cell carcinoma utilizing CMS classification Tajiri, Kensuke Sudo, Tomoya Ishi, Kazuo Kawahara, Akihiko Nagasu, Sachiko Shimomura, Susumu Yuge, Kotaro Katagiri, Mitsuhiro Yomoda, Takato Fujiyoshi, Kenji Kenichi, Koshi Ohchi, Takafumi Yoshida, Takefumi Mizobe, Tomoaki Fujita, Fumihiko Akiba, Jun Akagi, Yoshito Mol Clin Oncol Articles Signet ring cell carcinoma (SRCC) is a rare pathological type of colorectal cancer, of which the clinicopathological features and genetic background have not yet been fully investigated. Previous research has focused on the optimization of colorectal cancer treatment utilizing consensus molecular subtyping (CMS). However, it is not known what type of CMS would be designated to SRCC treatment. In the current study, of 1,350 patients diagnosed with colorectal cancer who underwent surgery, 14 were diagnosed with SRCC. The case-control cohort that fit the clinical background of the SRCC case was constructed. Statistical comparison between the SRCC group and the case-control cohort was performed among clinicopathological variables. SRCC and well to moderately adenocarcinoma case mRNA were submitted to microarray analysis and CMS analysis. Compared with the case-control cohort, the SRCC group was located more in the right-sided colon, the lymphatic invasion was more severe and the peritoneal dissemination was more frequent. The cancer-specific survival and the progression-free survival were significantly worse in the SRCC group compared with the case-control cohort. Microarray and CMS analysis identified that one SRCC case was significantly well assigned in the CMS 4 group and the other case was assigned in the CMS 1 group. Gene set analysis revealed the upregulation of EMT related genes and the downregulation of fatty acid, glycolysis, differentiation, MYC, HNF4A, DNA repair genes. In conclusion, the clinical characteristics of SRCC are severe but there is a possibility of the presence of different phenotypes according to CMS analysis. D.A. Spandidos 2021-05 2021-03-12 /pmc/articles/PMC7976453/ /pubmed/33767867 http://dx.doi.org/10.3892/mco.2021.2260 Text en Copyright: © Tajiri et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Tajiri, Kensuke Sudo, Tomoya Ishi, Kazuo Kawahara, Akihiko Nagasu, Sachiko Shimomura, Susumu Yuge, Kotaro Katagiri, Mitsuhiro Yomoda, Takato Fujiyoshi, Kenji Kenichi, Koshi Ohchi, Takafumi Yoshida, Takefumi Mizobe, Tomoaki Fujita, Fumihiko Akiba, Jun Akagi, Yoshito Investigation of clinicopathological characters and gene expression features in colorectal signet-ring cell carcinoma utilizing CMS classification |
title | Investigation of clinicopathological characters and gene expression features in colorectal signet-ring cell carcinoma utilizing CMS classification |
title_full | Investigation of clinicopathological characters and gene expression features in colorectal signet-ring cell carcinoma utilizing CMS classification |
title_fullStr | Investigation of clinicopathological characters and gene expression features in colorectal signet-ring cell carcinoma utilizing CMS classification |
title_full_unstemmed | Investigation of clinicopathological characters and gene expression features in colorectal signet-ring cell carcinoma utilizing CMS classification |
title_short | Investigation of clinicopathological characters and gene expression features in colorectal signet-ring cell carcinoma utilizing CMS classification |
title_sort | investigation of clinicopathological characters and gene expression features in colorectal signet-ring cell carcinoma utilizing cms classification |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976453/ https://www.ncbi.nlm.nih.gov/pubmed/33767867 http://dx.doi.org/10.3892/mco.2021.2260 |
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