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Oncological and prognostic impact of lymphovascular invasion in Colorectal Cancer patients

Objectives: Lymphovascular invasion (LVI) is correlated with unfavorable prognoses in several types of cancers. We aimed to identify the informative features associated with LVI and to determine its prognostic value in colorectal cancer (CRC) patients. Methods: We retrospectively analyzed 1,474 CRC...

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Autores principales: Wang, Xiaofei, Cao, Yinghao, Ding, Miaomiao, Liu, Junqi, Zuo, Xiaoxiao, Li, Hongfei, Fan, Ruitai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976558/
https://www.ncbi.nlm.nih.gov/pubmed/33746588
http://dx.doi.org/10.7150/ijms.53555
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author Wang, Xiaofei
Cao, Yinghao
Ding, Miaomiao
Liu, Junqi
Zuo, Xiaoxiao
Li, Hongfei
Fan, Ruitai
author_facet Wang, Xiaofei
Cao, Yinghao
Ding, Miaomiao
Liu, Junqi
Zuo, Xiaoxiao
Li, Hongfei
Fan, Ruitai
author_sort Wang, Xiaofei
collection PubMed
description Objectives: Lymphovascular invasion (LVI) is correlated with unfavorable prognoses in several types of cancers. We aimed to identify the informative features associated with LVI and to determine its prognostic value in colorectal cancer (CRC) patients. Methods: We retrospectively analyzed 1,474 CRC patients admitted in Wuhan Union Hospital between 2013 and 2017 as the development cohort and 549 CRC patients from The Cancer Genome Atlas (TCGA) database as the validation cohort. Logistical and Cox regression analyses were conducted to determine the oncological and prognostic significance of LVI in CRC patients. A survival nomogram based on LVI status was established using the Wuhan Union cohort and validated using TCGA cohort. Results: The LVI detection rates were 21.64% in the Wuhan Union cohort and 35.15% in TCGA cohort. LVI was closely correlated with advanced T stage, N stage, and TNM stage. LVI positivity was an independent biomarker for unfavorable overall survival (hazard ratio [HR]=2.25, 95% confidence interval [CI]=1.70-2.96, P<0.0001) and worse disease-free survival (HR=2.34, 95% CI=1.76-3.12, P<0.0001) in CRC patients. The survival nomogram incorporating LVI exhibited good predictive performance and reliability in the Wuhan Union cohort and TCGA cohort. Conclusion: LVI is a significant indicator of advanced stage and is remarkably correlated with worse prognosis in CRC patients. The survival nomogram incorporating LVI may assist clinicians to better strategize the therapeutic options for patients with CRC.
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spelling pubmed-79765582021-03-19 Oncological and prognostic impact of lymphovascular invasion in Colorectal Cancer patients Wang, Xiaofei Cao, Yinghao Ding, Miaomiao Liu, Junqi Zuo, Xiaoxiao Li, Hongfei Fan, Ruitai Int J Med Sci Research Paper Objectives: Lymphovascular invasion (LVI) is correlated with unfavorable prognoses in several types of cancers. We aimed to identify the informative features associated with LVI and to determine its prognostic value in colorectal cancer (CRC) patients. Methods: We retrospectively analyzed 1,474 CRC patients admitted in Wuhan Union Hospital between 2013 and 2017 as the development cohort and 549 CRC patients from The Cancer Genome Atlas (TCGA) database as the validation cohort. Logistical and Cox regression analyses were conducted to determine the oncological and prognostic significance of LVI in CRC patients. A survival nomogram based on LVI status was established using the Wuhan Union cohort and validated using TCGA cohort. Results: The LVI detection rates were 21.64% in the Wuhan Union cohort and 35.15% in TCGA cohort. LVI was closely correlated with advanced T stage, N stage, and TNM stage. LVI positivity was an independent biomarker for unfavorable overall survival (hazard ratio [HR]=2.25, 95% confidence interval [CI]=1.70-2.96, P<0.0001) and worse disease-free survival (HR=2.34, 95% CI=1.76-3.12, P<0.0001) in CRC patients. The survival nomogram incorporating LVI exhibited good predictive performance and reliability in the Wuhan Union cohort and TCGA cohort. Conclusion: LVI is a significant indicator of advanced stage and is remarkably correlated with worse prognosis in CRC patients. The survival nomogram incorporating LVI may assist clinicians to better strategize the therapeutic options for patients with CRC. Ivyspring International Publisher 2021-02-10 /pmc/articles/PMC7976558/ /pubmed/33746588 http://dx.doi.org/10.7150/ijms.53555 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Xiaofei
Cao, Yinghao
Ding, Miaomiao
Liu, Junqi
Zuo, Xiaoxiao
Li, Hongfei
Fan, Ruitai
Oncological and prognostic impact of lymphovascular invasion in Colorectal Cancer patients
title Oncological and prognostic impact of lymphovascular invasion in Colorectal Cancer patients
title_full Oncological and prognostic impact of lymphovascular invasion in Colorectal Cancer patients
title_fullStr Oncological and prognostic impact of lymphovascular invasion in Colorectal Cancer patients
title_full_unstemmed Oncological and prognostic impact of lymphovascular invasion in Colorectal Cancer patients
title_short Oncological and prognostic impact of lymphovascular invasion in Colorectal Cancer patients
title_sort oncological and prognostic impact of lymphovascular invasion in colorectal cancer patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976558/
https://www.ncbi.nlm.nih.gov/pubmed/33746588
http://dx.doi.org/10.7150/ijms.53555
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