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Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past

Rheumatoid arthritis (RA) is a systemic chronic autoimmune inflammatory disease which is mainly characterized by synovitis and results in a severe burden for both the individual and society. To date, the underlying mechanisms of RA are still poorly understood. Pentraxin 3 (PTX3) is a typical long pe...

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Autores principales: Qiu, Cheng, Han, Yichao, Zhang, Hanwen, Liu, Tianyi, Hou, Haodong, Luo, Dan, Yu, Mingzhi, Bian, Kai, Zhao, Yunpeng, Xiao, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976587/
https://www.ncbi.nlm.nih.gov/pubmed/33746606
http://dx.doi.org/10.7150/ijms.54787
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author Qiu, Cheng
Han, Yichao
Zhang, Hanwen
Liu, Tianyi
Hou, Haodong
Luo, Dan
Yu, Mingzhi
Bian, Kai
Zhao, Yunpeng
Xiao, Xing
author_facet Qiu, Cheng
Han, Yichao
Zhang, Hanwen
Liu, Tianyi
Hou, Haodong
Luo, Dan
Yu, Mingzhi
Bian, Kai
Zhao, Yunpeng
Xiao, Xing
author_sort Qiu, Cheng
collection PubMed
description Rheumatoid arthritis (RA) is a systemic chronic autoimmune inflammatory disease which is mainly characterized by synovitis and results in a severe burden for both the individual and society. To date, the underlying mechanisms of RA are still poorly understood. Pentraxin 3 (PTX3) is a typical long pentraxin protein which has been highly conserved during evolution. Meanwhile, functions as well as properties of PTX3 have been extensively studied. Several studies identified that PTX3 plays a predominate role in infection, inflammation, immunity and tumor. Interestingly, PTX3 has also been verified to be closely associated with development of RA. We therefore accomplished an elaboration of the relationships between PTX3 and RA. Herein, we mainly focus on the associated cell types and cognate cytokines involved in RA, in combination with PTX3. This review infers the insight into the interaction of PTX3 in RA and aims to provide novel clues for potential therapeutic target of RA in clinic.
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spelling pubmed-79765872021-03-19 Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past Qiu, Cheng Han, Yichao Zhang, Hanwen Liu, Tianyi Hou, Haodong Luo, Dan Yu, Mingzhi Bian, Kai Zhao, Yunpeng Xiao, Xing Int J Med Sci Review Rheumatoid arthritis (RA) is a systemic chronic autoimmune inflammatory disease which is mainly characterized by synovitis and results in a severe burden for both the individual and society. To date, the underlying mechanisms of RA are still poorly understood. Pentraxin 3 (PTX3) is a typical long pentraxin protein which has been highly conserved during evolution. Meanwhile, functions as well as properties of PTX3 have been extensively studied. Several studies identified that PTX3 plays a predominate role in infection, inflammation, immunity and tumor. Interestingly, PTX3 has also been verified to be closely associated with development of RA. We therefore accomplished an elaboration of the relationships between PTX3 and RA. Herein, we mainly focus on the associated cell types and cognate cytokines involved in RA, in combination with PTX3. This review infers the insight into the interaction of PTX3 in RA and aims to provide novel clues for potential therapeutic target of RA in clinic. Ivyspring International Publisher 2021-03-03 /pmc/articles/PMC7976587/ /pubmed/33746606 http://dx.doi.org/10.7150/ijms.54787 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Qiu, Cheng
Han, Yichao
Zhang, Hanwen
Liu, Tianyi
Hou, Haodong
Luo, Dan
Yu, Mingzhi
Bian, Kai
Zhao, Yunpeng
Xiao, Xing
Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past
title Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past
title_full Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past
title_fullStr Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past
title_full_unstemmed Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past
title_short Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past
title_sort perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976587/
https://www.ncbi.nlm.nih.gov/pubmed/33746606
http://dx.doi.org/10.7150/ijms.54787
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