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Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with immunosuppressive functions; these cells play a key role in infection, immunization, chronic inflammation, and cancer. Recent studies have reported that immunosuppression plays an important role in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976590/ https://www.ncbi.nlm.nih.gov/pubmed/33746599 http://dx.doi.org/10.7150/ijms.51946 |
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author | Kawai, Hotaka Oo, May Wathone Tsujigiwa, Hidetsugu Nakano, Keisuke Takabatake, Kiyofumi Sukegawa, Shintaro Nagatsuka, Hitoshi |
author_facet | Kawai, Hotaka Oo, May Wathone Tsujigiwa, Hidetsugu Nakano, Keisuke Takabatake, Kiyofumi Sukegawa, Shintaro Nagatsuka, Hitoshi |
author_sort | Kawai, Hotaka |
collection | PubMed |
description | Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with immunosuppressive functions; these cells play a key role in infection, immunization, chronic inflammation, and cancer. Recent studies have reported that immunosuppression plays an important role in the healing process of tissues and that Treg play an important role in fracture healing. MDSCs suppress active T cell proliferation and reduce the severity of arthritis in mice and humans. Together, these findings suggest that MDSCs play a role in bone biotransformation. In the present study, we examined the role of MDSCs in the bone healing process by creating a bone injury at the tibial epiphysis in mice. MDSCs were identified by CD11b and GR1 immunohistochemistry and their role in new bone formation was observed by detection of Runx2 and osteocalcin expression. Significant numbers of MDSCs were observed in transitional areas from the reactionary to repair stages. Interestingly, MDSCs exhibited Runx2 and osteocalcin expression in the transitional area but not in the reactionary area. And at the same area, cllagene-1 and ALP expression level increased in osteoblast progenitor cells. These data is suggesting that MDSCs emerge to suppress inflammation and support new bone formation. Here, we report, for the first time (to our knowledge), the role of MDSCs in the initiation of bone formation. MDSC appeared at the transition from inflammation to bone making and regulates bone healing by suppressing inflammation. |
format | Online Article Text |
id | pubmed-7976590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-79765902021-03-19 Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process Kawai, Hotaka Oo, May Wathone Tsujigiwa, Hidetsugu Nakano, Keisuke Takabatake, Kiyofumi Sukegawa, Shintaro Nagatsuka, Hitoshi Int J Med Sci Research Paper Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with immunosuppressive functions; these cells play a key role in infection, immunization, chronic inflammation, and cancer. Recent studies have reported that immunosuppression plays an important role in the healing process of tissues and that Treg play an important role in fracture healing. MDSCs suppress active T cell proliferation and reduce the severity of arthritis in mice and humans. Together, these findings suggest that MDSCs play a role in bone biotransformation. In the present study, we examined the role of MDSCs in the bone healing process by creating a bone injury at the tibial epiphysis in mice. MDSCs were identified by CD11b and GR1 immunohistochemistry and their role in new bone formation was observed by detection of Runx2 and osteocalcin expression. Significant numbers of MDSCs were observed in transitional areas from the reactionary to repair stages. Interestingly, MDSCs exhibited Runx2 and osteocalcin expression in the transitional area but not in the reactionary area. And at the same area, cllagene-1 and ALP expression level increased in osteoblast progenitor cells. These data is suggesting that MDSCs emerge to suppress inflammation and support new bone formation. Here, we report, for the first time (to our knowledge), the role of MDSCs in the initiation of bone formation. MDSC appeared at the transition from inflammation to bone making and regulates bone healing by suppressing inflammation. Ivyspring International Publisher 2021-02-19 /pmc/articles/PMC7976590/ /pubmed/33746599 http://dx.doi.org/10.7150/ijms.51946 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Kawai, Hotaka Oo, May Wathone Tsujigiwa, Hidetsugu Nakano, Keisuke Takabatake, Kiyofumi Sukegawa, Shintaro Nagatsuka, Hitoshi Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process |
title | Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process |
title_full | Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process |
title_fullStr | Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process |
title_full_unstemmed | Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process |
title_short | Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process |
title_sort | potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976590/ https://www.ncbi.nlm.nih.gov/pubmed/33746599 http://dx.doi.org/10.7150/ijms.51946 |
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