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Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with immunosuppressive functions; these cells play a key role in infection, immunization, chronic inflammation, and cancer. Recent studies have reported that immunosuppression plays an important role in...

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Autores principales: Kawai, Hotaka, Oo, May Wathone, Tsujigiwa, Hidetsugu, Nakano, Keisuke, Takabatake, Kiyofumi, Sukegawa, Shintaro, Nagatsuka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976590/
https://www.ncbi.nlm.nih.gov/pubmed/33746599
http://dx.doi.org/10.7150/ijms.51946
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author Kawai, Hotaka
Oo, May Wathone
Tsujigiwa, Hidetsugu
Nakano, Keisuke
Takabatake, Kiyofumi
Sukegawa, Shintaro
Nagatsuka, Hitoshi
author_facet Kawai, Hotaka
Oo, May Wathone
Tsujigiwa, Hidetsugu
Nakano, Keisuke
Takabatake, Kiyofumi
Sukegawa, Shintaro
Nagatsuka, Hitoshi
author_sort Kawai, Hotaka
collection PubMed
description Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with immunosuppressive functions; these cells play a key role in infection, immunization, chronic inflammation, and cancer. Recent studies have reported that immunosuppression plays an important role in the healing process of tissues and that Treg play an important role in fracture healing. MDSCs suppress active T cell proliferation and reduce the severity of arthritis in mice and humans. Together, these findings suggest that MDSCs play a role in bone biotransformation. In the present study, we examined the role of MDSCs in the bone healing process by creating a bone injury at the tibial epiphysis in mice. MDSCs were identified by CD11b and GR1 immunohistochemistry and their role in new bone formation was observed by detection of Runx2 and osteocalcin expression. Significant numbers of MDSCs were observed in transitional areas from the reactionary to repair stages. Interestingly, MDSCs exhibited Runx2 and osteocalcin expression in the transitional area but not in the reactionary area. And at the same area, cllagene-1 and ALP expression level increased in osteoblast progenitor cells. These data is suggesting that MDSCs emerge to suppress inflammation and support new bone formation. Here, we report, for the first time (to our knowledge), the role of MDSCs in the initiation of bone formation. MDSC appeared at the transition from inflammation to bone making and regulates bone healing by suppressing inflammation.
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spelling pubmed-79765902021-03-19 Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process Kawai, Hotaka Oo, May Wathone Tsujigiwa, Hidetsugu Nakano, Keisuke Takabatake, Kiyofumi Sukegawa, Shintaro Nagatsuka, Hitoshi Int J Med Sci Research Paper Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with immunosuppressive functions; these cells play a key role in infection, immunization, chronic inflammation, and cancer. Recent studies have reported that immunosuppression plays an important role in the healing process of tissues and that Treg play an important role in fracture healing. MDSCs suppress active T cell proliferation and reduce the severity of arthritis in mice and humans. Together, these findings suggest that MDSCs play a role in bone biotransformation. In the present study, we examined the role of MDSCs in the bone healing process by creating a bone injury at the tibial epiphysis in mice. MDSCs were identified by CD11b and GR1 immunohistochemistry and their role in new bone formation was observed by detection of Runx2 and osteocalcin expression. Significant numbers of MDSCs were observed in transitional areas from the reactionary to repair stages. Interestingly, MDSCs exhibited Runx2 and osteocalcin expression in the transitional area but not in the reactionary area. And at the same area, cllagene-1 and ALP expression level increased in osteoblast progenitor cells. These data is suggesting that MDSCs emerge to suppress inflammation and support new bone formation. Here, we report, for the first time (to our knowledge), the role of MDSCs in the initiation of bone formation. MDSC appeared at the transition from inflammation to bone making and regulates bone healing by suppressing inflammation. Ivyspring International Publisher 2021-02-19 /pmc/articles/PMC7976590/ /pubmed/33746599 http://dx.doi.org/10.7150/ijms.51946 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Kawai, Hotaka
Oo, May Wathone
Tsujigiwa, Hidetsugu
Nakano, Keisuke
Takabatake, Kiyofumi
Sukegawa, Shintaro
Nagatsuka, Hitoshi
Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
title Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
title_full Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
title_fullStr Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
title_full_unstemmed Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
title_short Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
title_sort potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976590/
https://www.ncbi.nlm.nih.gov/pubmed/33746599
http://dx.doi.org/10.7150/ijms.51946
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