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Liver transplantation in patients with neuroendocrine tumors: a case series and literature review

Neuroendocrine tumors (NET) are a rare and heterogeneous group of neoplasms with variable biological behavior. They frequently metastasize to the liver, requiring active, multimodality treatment. Surgical resection, possible in only a minority of cases, was until recently the only potentially curati...

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Autores principales: Ilić, Diana, Kunac, Nino, Borčić, Tina, Dinjar, Petra, Kujundžić, Mišetić, Zrinka, Dolić, Sobočan, Nikola, Lalovac, Miloš, Mijić, Maja, Međimurec, Goran, Kocman, Branislav, Mikolašević, Ivana, Filipec Kanižaj, Tajana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976884/
https://www.ncbi.nlm.nih.gov/pubmed/33660960
http://dx.doi.org/10.3325/cmj.2021.62.44
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author Ilić, Diana
Kunac, Nino
Borčić, Tina
Dinjar, Petra
Kujundžić,
Mišetić, Zrinka
Dolić,
Sobočan, Nikola
Lalovac, Miloš
Mijić, Maja
Međimurec, Goran
Kocman, Branislav
Mikolašević, Ivana
Filipec Kanižaj, Tajana
author_facet Ilić, Diana
Kunac, Nino
Borčić, Tina
Dinjar, Petra
Kujundžić,
Mišetić, Zrinka
Dolić,
Sobočan, Nikola
Lalovac, Miloš
Mijić, Maja
Međimurec, Goran
Kocman, Branislav
Mikolašević, Ivana
Filipec Kanižaj, Tajana
author_sort Ilić, Diana
collection PubMed
description Neuroendocrine tumors (NET) are a rare and heterogeneous group of neoplasms with variable biological behavior. They frequently metastasize to the liver, requiring active, multimodality treatment. Surgical resection, possible in only a minority of cases, was until recently the only potentially curative option. For unresectable NET with liver metastases, liver transplantation (LT) emerged as a potential curative treatment due to relatively slow growth and indolent behavior of the metastases. In this case series with literature review, we retrospectively analyzed the characteristics of 12 highly selected patients with metastatic NET disease as an indication for LT treated in our center. We also summarized the proposed prognostic factors, and evaluated and compared the existing selection criteria. The main poor prognostic factors in our patients were high grade NET and primary tumor in the pancreas. Inconsistent liver transplantation outcome parameters make it difficult to standardize patient selection criteria. There is a need for further studies that would fully elucidate the curative potential of LT in patients diagnosed with NET.
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spelling pubmed-79768842021-03-31 Liver transplantation in patients with neuroendocrine tumors: a case series and literature review Ilić, Diana Kunac, Nino Borčić, Tina Dinjar, Petra Kujundžić, Mišetić, Zrinka Dolić, Sobočan, Nikola Lalovac, Miloš Mijić, Maja Međimurec, Goran Kocman, Branislav Mikolašević, Ivana Filipec Kanižaj, Tajana Croat Med J Case Report Neuroendocrine tumors (NET) are a rare and heterogeneous group of neoplasms with variable biological behavior. They frequently metastasize to the liver, requiring active, multimodality treatment. Surgical resection, possible in only a minority of cases, was until recently the only potentially curative option. For unresectable NET with liver metastases, liver transplantation (LT) emerged as a potential curative treatment due to relatively slow growth and indolent behavior of the metastases. In this case series with literature review, we retrospectively analyzed the characteristics of 12 highly selected patients with metastatic NET disease as an indication for LT treated in our center. We also summarized the proposed prognostic factors, and evaluated and compared the existing selection criteria. The main poor prognostic factors in our patients were high grade NET and primary tumor in the pancreas. Inconsistent liver transplantation outcome parameters make it difficult to standardize patient selection criteria. There is a need for further studies that would fully elucidate the curative potential of LT in patients diagnosed with NET. Croatian Medical Schools 2021-02 /pmc/articles/PMC7976884/ /pubmed/33660960 http://dx.doi.org/10.3325/cmj.2021.62.44 Text en Copyright © 2021 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ilić, Diana
Kunac, Nino
Borčić, Tina
Dinjar, Petra
Kujundžić,
Mišetić, Zrinka
Dolić,
Sobočan, Nikola
Lalovac, Miloš
Mijić, Maja
Međimurec, Goran
Kocman, Branislav
Mikolašević, Ivana
Filipec Kanižaj, Tajana
Liver transplantation in patients with neuroendocrine tumors: a case series and literature review
title Liver transplantation in patients with neuroendocrine tumors: a case series and literature review
title_full Liver transplantation in patients with neuroendocrine tumors: a case series and literature review
title_fullStr Liver transplantation in patients with neuroendocrine tumors: a case series and literature review
title_full_unstemmed Liver transplantation in patients with neuroendocrine tumors: a case series and literature review
title_short Liver transplantation in patients with neuroendocrine tumors: a case series and literature review
title_sort liver transplantation in patients with neuroendocrine tumors: a case series and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976884/
https://www.ncbi.nlm.nih.gov/pubmed/33660960
http://dx.doi.org/10.3325/cmj.2021.62.44
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