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Quantitative Angiographic Assessment of Aortic Regurgitation after Transcatheter Aortic Valve Implantation among Three Balloon-Expandable Valves

OBJECTIVES: The aim of the present analysis is to compare the quantitative angiographic aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) among three balloon-expandable valves. BACKGROUND: Quantitative videodensitometric aortography is an objective, accurate, and reprodu...

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Autores principales: Kawashima, Hideyuki, Wang, Rutao, Mylotte, Darren, Jagielak, Dariusz, De Marco, Frederico, Ielasi, Alfonso, Onuma, Yoshinobu, den Heijer, Peter, Terkelsen, Christian Juhl, Wijns, William, Serruys, Patrick W., Soliman, Osama
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977026/
https://www.ncbi.nlm.nih.gov/pubmed/33833944
http://dx.doi.org/10.5334/gh.959
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author Kawashima, Hideyuki
Wang, Rutao
Mylotte, Darren
Jagielak, Dariusz
De Marco, Frederico
Ielasi, Alfonso
Onuma, Yoshinobu
den Heijer, Peter
Terkelsen, Christian Juhl
Wijns, William
Serruys, Patrick W.
Soliman, Osama
author_facet Kawashima, Hideyuki
Wang, Rutao
Mylotte, Darren
Jagielak, Dariusz
De Marco, Frederico
Ielasi, Alfonso
Onuma, Yoshinobu
den Heijer, Peter
Terkelsen, Christian Juhl
Wijns, William
Serruys, Patrick W.
Soliman, Osama
author_sort Kawashima, Hideyuki
collection PubMed
description OBJECTIVES: The aim of the present analysis is to compare the quantitative angiographic aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) among three balloon-expandable valves. BACKGROUND: Quantitative videodensitometric aortography is an objective, accurate, and reproducible tool for adjudication of AR following TAVI. METHODS: This is a retrospective corelab analysis, independent from industry, of aortograms from patients treated with TAVI using the balloon-expandable Myval transcatheter heart valve (THV) (Meril Life Sciences Pvt. Ltd., India), Sapien 3, and XT THVs (Edwards Lifesciences, Irvine, CA, USA). The study comprised of 108 analyzable aortograms from consecutive patients in a multicenter European registry who underwent Myval THV implantation. The results of quantitative assessment of AR in the Sapien 3 THV (n = 397) and Sapien XT THV (n = 239) were retrieved from a published pooled database. RESULTS: The Myval THV had the lowest proportion of patients with moderate or severe angiographic quantitative AR (2.8%) compared to the Sapien 3 THV (8.3%; p = 0.049) and Sapien XT THV (10.9%; p = 0.012). Furthermore, the Myval THV had the lowest mean angiographic quantitative AR (6.3 ± 6.3%), followed by Sapien 3 THV (7.6 ± 7.1%) and Sapien XT THV (8.8 ± 7.5%), and it was significantly lower than that of the Sapien XT THV (p = 0.006), but not significantly different from Sapien 3 THV (p = 0.246). CONCLUSION: The Myval THV, in comparison with other BEV’s analyzed in our database, showed a lower occurrence of moderate or severe AR after TAVI. These results should be confirmed in prospective cohorts of randomized patients with head-to-head THV comparisons.
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spelling pubmed-79770262021-04-07 Quantitative Angiographic Assessment of Aortic Regurgitation after Transcatheter Aortic Valve Implantation among Three Balloon-Expandable Valves Kawashima, Hideyuki Wang, Rutao Mylotte, Darren Jagielak, Dariusz De Marco, Frederico Ielasi, Alfonso Onuma, Yoshinobu den Heijer, Peter Terkelsen, Christian Juhl Wijns, William Serruys, Patrick W. Soliman, Osama Glob Heart Original Research OBJECTIVES: The aim of the present analysis is to compare the quantitative angiographic aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) among three balloon-expandable valves. BACKGROUND: Quantitative videodensitometric aortography is an objective, accurate, and reproducible tool for adjudication of AR following TAVI. METHODS: This is a retrospective corelab analysis, independent from industry, of aortograms from patients treated with TAVI using the balloon-expandable Myval transcatheter heart valve (THV) (Meril Life Sciences Pvt. Ltd., India), Sapien 3, and XT THVs (Edwards Lifesciences, Irvine, CA, USA). The study comprised of 108 analyzable aortograms from consecutive patients in a multicenter European registry who underwent Myval THV implantation. The results of quantitative assessment of AR in the Sapien 3 THV (n = 397) and Sapien XT THV (n = 239) were retrieved from a published pooled database. RESULTS: The Myval THV had the lowest proportion of patients with moderate or severe angiographic quantitative AR (2.8%) compared to the Sapien 3 THV (8.3%; p = 0.049) and Sapien XT THV (10.9%; p = 0.012). Furthermore, the Myval THV had the lowest mean angiographic quantitative AR (6.3 ± 6.3%), followed by Sapien 3 THV (7.6 ± 7.1%) and Sapien XT THV (8.8 ± 7.5%), and it was significantly lower than that of the Sapien XT THV (p = 0.006), but not significantly different from Sapien 3 THV (p = 0.246). CONCLUSION: The Myval THV, in comparison with other BEV’s analyzed in our database, showed a lower occurrence of moderate or severe AR after TAVI. These results should be confirmed in prospective cohorts of randomized patients with head-to-head THV comparisons. Ubiquity Press 2021-03-19 /pmc/articles/PMC7977026/ /pubmed/33833944 http://dx.doi.org/10.5334/gh.959 Text en Copyright: © 2021 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Research
Kawashima, Hideyuki
Wang, Rutao
Mylotte, Darren
Jagielak, Dariusz
De Marco, Frederico
Ielasi, Alfonso
Onuma, Yoshinobu
den Heijer, Peter
Terkelsen, Christian Juhl
Wijns, William
Serruys, Patrick W.
Soliman, Osama
Quantitative Angiographic Assessment of Aortic Regurgitation after Transcatheter Aortic Valve Implantation among Three Balloon-Expandable Valves
title Quantitative Angiographic Assessment of Aortic Regurgitation after Transcatheter Aortic Valve Implantation among Three Balloon-Expandable Valves
title_full Quantitative Angiographic Assessment of Aortic Regurgitation after Transcatheter Aortic Valve Implantation among Three Balloon-Expandable Valves
title_fullStr Quantitative Angiographic Assessment of Aortic Regurgitation after Transcatheter Aortic Valve Implantation among Three Balloon-Expandable Valves
title_full_unstemmed Quantitative Angiographic Assessment of Aortic Regurgitation after Transcatheter Aortic Valve Implantation among Three Balloon-Expandable Valves
title_short Quantitative Angiographic Assessment of Aortic Regurgitation after Transcatheter Aortic Valve Implantation among Three Balloon-Expandable Valves
title_sort quantitative angiographic assessment of aortic regurgitation after transcatheter aortic valve implantation among three balloon-expandable valves
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977026/
https://www.ncbi.nlm.nih.gov/pubmed/33833944
http://dx.doi.org/10.5334/gh.959
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