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COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study
OBJECTIVES: To describe the frequency of symptoms compatible with SARS-CoV-2 infection in immunocompromised children and young people in the UK during the SARS-CoV-2 pandemic. To describe patient/parent anxiety regarding SARS-CoV-2 infection in this cohort. DESIGN: A prospective observational cohort...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977081/ https://www.ncbi.nlm.nih.gov/pubmed/33737439 http://dx.doi.org/10.1136/bmjopen-2020-044899 |
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author | Shaunak, Meera Patel, Ravin Driessens, Corine Mills, Lynne Leahy, Alice Gbesemete, Diane Owens, Daniel R Lucas, Jane S Faust, Saul N de Graaf, Hans |
author_facet | Shaunak, Meera Patel, Ravin Driessens, Corine Mills, Lynne Leahy, Alice Gbesemete, Diane Owens, Daniel R Lucas, Jane S Faust, Saul N de Graaf, Hans |
author_sort | Shaunak, Meera |
collection | PubMed |
description | OBJECTIVES: To describe the frequency of symptoms compatible with SARS-CoV-2 infection in immunocompromised children and young people in the UK during the SARS-CoV-2 pandemic. To describe patient/parent anxiety regarding SARS-CoV-2 infection in this cohort. DESIGN: A prospective observational cohort study. SETTING: 46 centres across the UK between 16 March and 4 July 2020. A weekly online questionnaire based on the International Severe Acute Respiratory and emerging Infections Consortium-WHO Case Report Form was used to collect participant reported data on symptoms, test results, National Health Service attendance, hospital admission and impact on daily life. PARTICIPANTS: 1490 immunocompromised children, defined as those requiring an annual influenza vaccination due to their underlying condition or medication. MAIN OUTCOME MEASURES: Incidence of SARS-CoV-2-like symptoms and patient/parent anxiety score. RESULTS: Over 16 weeks during the first wave of the pandemic, no SARS-CoV-2 infection was diagnosed in this large immunocompromised paediatric cohort (median age 11 years, 54.4% female). 110 symptomatic participants underwent a test for SARS-CoV-2; all were negative. 922 (67.4%) participants reported at least one symptom consistent with suspected SARS-CoV-2 infection over the study period. 476 (34.8%) reported three or more symptoms. The most frequently reported symptoms included joint pain, fatigue, headache, nausea and muscle pain. SARS-CoV-2 testing during this period was performed on admitted patients only. 137 participants had their medication suspended or changed during the study period due to assumed COVID-19 disease risk. 62% reported high levels of anxiety (scores of 7–10 out of 10) at the start of the study, with anxiety levels remaining high throughout the study period. CONCLUSIONS: Although symptoms related to SARS-CoV-2 infection in children were common, there were no positive tests in this large immunocompromised cohort. Symptom-based screening to facilitate early detection of SARS-CoV-2 infection may not be helpful in these individuals. Patient/parent anxiety about SARS-CoV-2 infection was high. TRIAL REGISTRATION NUMBER: NCT04382508. |
format | Online Article Text |
id | pubmed-7977081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-79770812021-03-19 COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study Shaunak, Meera Patel, Ravin Driessens, Corine Mills, Lynne Leahy, Alice Gbesemete, Diane Owens, Daniel R Lucas, Jane S Faust, Saul N de Graaf, Hans BMJ Open Paediatrics OBJECTIVES: To describe the frequency of symptoms compatible with SARS-CoV-2 infection in immunocompromised children and young people in the UK during the SARS-CoV-2 pandemic. To describe patient/parent anxiety regarding SARS-CoV-2 infection in this cohort. DESIGN: A prospective observational cohort study. SETTING: 46 centres across the UK between 16 March and 4 July 2020. A weekly online questionnaire based on the International Severe Acute Respiratory and emerging Infections Consortium-WHO Case Report Form was used to collect participant reported data on symptoms, test results, National Health Service attendance, hospital admission and impact on daily life. PARTICIPANTS: 1490 immunocompromised children, defined as those requiring an annual influenza vaccination due to their underlying condition or medication. MAIN OUTCOME MEASURES: Incidence of SARS-CoV-2-like symptoms and patient/parent anxiety score. RESULTS: Over 16 weeks during the first wave of the pandemic, no SARS-CoV-2 infection was diagnosed in this large immunocompromised paediatric cohort (median age 11 years, 54.4% female). 110 symptomatic participants underwent a test for SARS-CoV-2; all were negative. 922 (67.4%) participants reported at least one symptom consistent with suspected SARS-CoV-2 infection over the study period. 476 (34.8%) reported three or more symptoms. The most frequently reported symptoms included joint pain, fatigue, headache, nausea and muscle pain. SARS-CoV-2 testing during this period was performed on admitted patients only. 137 participants had their medication suspended or changed during the study period due to assumed COVID-19 disease risk. 62% reported high levels of anxiety (scores of 7–10 out of 10) at the start of the study, with anxiety levels remaining high throughout the study period. CONCLUSIONS: Although symptoms related to SARS-CoV-2 infection in children were common, there were no positive tests in this large immunocompromised cohort. Symptom-based screening to facilitate early detection of SARS-CoV-2 infection may not be helpful in these individuals. Patient/parent anxiety about SARS-CoV-2 infection was high. TRIAL REGISTRATION NUMBER: NCT04382508. BMJ Publishing Group 2021-03-17 /pmc/articles/PMC7977081/ /pubmed/33737439 http://dx.doi.org/10.1136/bmjopen-2020-044899 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Paediatrics Shaunak, Meera Patel, Ravin Driessens, Corine Mills, Lynne Leahy, Alice Gbesemete, Diane Owens, Daniel R Lucas, Jane S Faust, Saul N de Graaf, Hans COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study |
title | COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study |
title_full | COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study |
title_fullStr | COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study |
title_full_unstemmed | COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study |
title_short | COVID-19 symptom surveillance in immunocompromised children and young people in the UK: a prospective observational cohort study |
title_sort | covid-19 symptom surveillance in immunocompromised children and young people in the uk: a prospective observational cohort study |
topic | Paediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977081/ https://www.ncbi.nlm.nih.gov/pubmed/33737439 http://dx.doi.org/10.1136/bmjopen-2020-044899 |
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