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Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study

BACKGROUND: The prevalence of osteopenia and osteoporosis is higher in patients with chronic kidney disease than that in the general population. Although physical exercise prevents bone loss in hemodialysis (HD) patients, previous studies have not focused on peritoneal dialysis (PD) patients. Theref...

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Autores principales: Watanabe, Kumi, Kamijo, Yuka, Yanagi, Mai, Ishibashi, Yoshitaka, Harada, Taku, Kohzuki, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977172/
https://www.ncbi.nlm.nih.gov/pubmed/33736592
http://dx.doi.org/10.1186/s12882-021-02289-y
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author Watanabe, Kumi
Kamijo, Yuka
Yanagi, Mai
Ishibashi, Yoshitaka
Harada, Taku
Kohzuki, Masahiro
author_facet Watanabe, Kumi
Kamijo, Yuka
Yanagi, Mai
Ishibashi, Yoshitaka
Harada, Taku
Kohzuki, Masahiro
author_sort Watanabe, Kumi
collection PubMed
description BACKGROUND: The prevalence of osteopenia and osteoporosis is higher in patients with chronic kidney disease than that in the general population. Although physical exercise prevents bone loss in hemodialysis (HD) patients, previous studies have not focused on peritoneal dialysis (PD) patients. Therefore, we aimed to evaluate the effects of home-based exercise on bone mineral density (BMD) in patients with PD. METHODS: Stable outpatients undergoing PD were randomly assigned to the intervention group (n = 26; male, 20; median age, 66 years) or usual-care group (n = 27; male, 21; median age, 64 years). Patients in the intervention group performed home-based exercises (resistance exercise, stretching, and aerobic exercise such as walking) for 6 months, whereas those in the usual-care group performed stretching and their usual physical activity. Based on dual X-ray absorptiometry, the primary outcomes were the BMD data of the lumbar spine and proximal femoral neck. Secondary outcomes included physical function and physical activity. Pre- and post-intervention values were compared. RESULTS: There was no significant within-group change in the BMD of the lumbar spine, femoral neck, and hip after 6 months of the exercise program. The intervention group had significantly improved 30-s chair-stand test, 6-min walk test, and physical activity results. CONCLUSIONS: Home-based exercises in patients with PD did not improve BMD at any of the sites evaluated. Improvement in physical function and physical activity may reduce the risk of falls in patients with PD. TRIAL REGISTRATION: UMIN Clinical Trials Registry, UMIN000041678. Registered September 4, 2020; retrospectively registered. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-021-02289-y.
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spelling pubmed-79771722021-03-22 Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study Watanabe, Kumi Kamijo, Yuka Yanagi, Mai Ishibashi, Yoshitaka Harada, Taku Kohzuki, Masahiro BMC Nephrol Research Article BACKGROUND: The prevalence of osteopenia and osteoporosis is higher in patients with chronic kidney disease than that in the general population. Although physical exercise prevents bone loss in hemodialysis (HD) patients, previous studies have not focused on peritoneal dialysis (PD) patients. Therefore, we aimed to evaluate the effects of home-based exercise on bone mineral density (BMD) in patients with PD. METHODS: Stable outpatients undergoing PD were randomly assigned to the intervention group (n = 26; male, 20; median age, 66 years) or usual-care group (n = 27; male, 21; median age, 64 years). Patients in the intervention group performed home-based exercises (resistance exercise, stretching, and aerobic exercise such as walking) for 6 months, whereas those in the usual-care group performed stretching and their usual physical activity. Based on dual X-ray absorptiometry, the primary outcomes were the BMD data of the lumbar spine and proximal femoral neck. Secondary outcomes included physical function and physical activity. Pre- and post-intervention values were compared. RESULTS: There was no significant within-group change in the BMD of the lumbar spine, femoral neck, and hip after 6 months of the exercise program. The intervention group had significantly improved 30-s chair-stand test, 6-min walk test, and physical activity results. CONCLUSIONS: Home-based exercises in patients with PD did not improve BMD at any of the sites evaluated. Improvement in physical function and physical activity may reduce the risk of falls in patients with PD. TRIAL REGISTRATION: UMIN Clinical Trials Registry, UMIN000041678. Registered September 4, 2020; retrospectively registered. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-021-02289-y. BioMed Central 2021-03-18 /pmc/articles/PMC7977172/ /pubmed/33736592 http://dx.doi.org/10.1186/s12882-021-02289-y Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Watanabe, Kumi
Kamijo, Yuka
Yanagi, Mai
Ishibashi, Yoshitaka
Harada, Taku
Kohzuki, Masahiro
Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study
title Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study
title_full Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study
title_fullStr Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study
title_full_unstemmed Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study
title_short Home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study
title_sort home-based exercise and bone mineral density in peritoneal dialysis patients: a randomized pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977172/
https://www.ncbi.nlm.nih.gov/pubmed/33736592
http://dx.doi.org/10.1186/s12882-021-02289-y
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