Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis

Rationale: Adenylosuccinate lyase (ADSL) is an essential enzyme for de novo purine biosynthesis. Here we sought to investigate the putative role of ADSL in colorectal carcinoma (CRC) carcinogenesis and response to antimetabolites. Methods: ADSL expression levels were assessed by immunohistochemistry...

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Detalles Bibliográficos
Autores principales: Taha-Mehlitz, Stephanie, Bianco, Gaia, Coto-Llerena, Mairene, Kancherla, Venkatesh, Bantug, Glenn R., Gallon, John, Ercan, Caner, Panebianco, Federica, Eppenberger-Castori, Serenella, von Strauss, Marco, Staubli, Sebastian, Bolli, Martin, Peterli, Ralph, Matter, Matthias S., Terracciano, Luigi M., von Flüe, Markus, Ng, Charlotte K.Y., Soysal, Savas D, Kollmar, Otto, Piscuoglio, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977451/
https://www.ncbi.nlm.nih.gov/pubmed/33754045
http://dx.doi.org/10.7150/thno.50051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977451/
https://www.ncbi.nlm.nih.gov/pubmed/33754045
http://dx.doi.org/10.7150/thno.50051

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