Cargando…

MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and currently has no effective treatment. Mainstream research on the mechanisms and therapeutic targets of AD is focused on the two most important hallmarks, Aβ and Tau, but the results from clinical studies are not encour...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Chunmei, Zou, Ting, Zhang, Miaoping, Fan, Weihao, Zhang, Tianzhen, Jiang, Yuling, Cai, Yujie, Chen, Feng, Chen, Xiongjin, Sun, Yuanhong, Zhao, Bin, Wang, Yan, Cui, Lili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977456/ https://www.ncbi.nlm.nih.gov/pubmed/33754051 http://dx.doi.org/10.7150/thno.53418

Ejemplares similares

TTC3-Mediated Protein Quality Control, A Potential Mechanism for Cognitive Impairment
por: Zhou, Xu, et al.
Publicado: (2021)

Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model
por: Mai, Hui, et al.
Publicado: (2019)

MicroRNA-146a Is a Wide-Reaching Neuroinflammatory Regulator and Potential Treatment Target in Neurological Diseases
por: Fan, Weihao, et al.
Publicado: (2020)

ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway
por: Chen, Feng, et al.
Publicado: (2023)

A single nucleotide polymorphism in primary-microRNA-146a reduces the expression of mature microRNA-146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease
por: ZHANG, BIN, et al.
Publicado: (2015)

Microglial immunophenotype in dementia with Alzheimer’s pathology
por: Minett, Thais, et al.
Publicado: (2016)

A Functional Polymorphism in the Promoter Region of MicroRNA-146a Is Associated with the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Patients
por: Cui, Lili, et al.
Publicado: (2014)

Molecular Regulation Mechanism of Microglial Autophagy in the Pathology of Alzheimer's Disease
por: Ou-Yang, Pei, et al.
Publicado: (2023)

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State
por: Saba, Reuben, et al.
Publicado: (2012)

Multiple roles of microRNA-146a in immune responses and hepatocellular carcinoma
por: Wang, Huihui, et al.
Publicado: (2019)

MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer’s disease
por: Wang, Gang, et al.
Publicado: (2016)

Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology
por: Cheng, Jinbo, et al.
Publicado: (2021)

Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer’s Disease
por: Zhao, Yuhai, et al.
Publicado: (2018)

Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
por: El Hajj, Hassan, et al.
Publicado: (2019)

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology
por: Smith, Amy M., et al.
Publicado: (2021)

Astroglial and microglial pathology in Down syndrome: Focus on Alzheimer's disease
por: García, Octavio, et al.
Publicado: (2022)

Microglial pathology
por: Streit, Wolfgang J, et al.
Publicado: (2014)

miR-146a reduces depressive behavior by inhibiting microglial activation
por: Liu, Chuan-Peng, et al.
Publicado: (2021)

Rs2015 Polymorphism in miRNA Target Site of Sirtuin2 Gene Is Associated with the Risk of Parkinson's Disease in Chinese Han Population
por: Chen, Xiongjin, et al.
Publicado: (2019)

Microglial microRNAs mediate sex-specific responses to tau pathology
por: Kodama, Lay, et al.
Publicado: (2019)

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody
por: Luo, Wenjie, et al.
Publicado: (2015)

TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer’s Disease-Associated Pathology and Cognitive Decline
por: Wang, Chenfei, et al.
Publicado: (2022)

microRNA-146a Signaling in Alzheimer's Disease (AD) and Prion Disease (PrD)
por: Lukiw, Walter J.
Publicado: (2020)

MicroRNA-146a promotes proliferation, migration, and invasion of HepG2 via regulating FLAP
por: Wang, Huihui, et al.
Publicado: (2022)

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
por: Zhong, Li, et al.
Publicado: (2019)

Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer's Disease
por: Chen, Yijing, et al.
Publicado: (2020)

Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment
por: Karthikeyan, Aparna, et al.
Publicado: (2018)

Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease
por: Zhou, Xiao-Gang, et al.
Publicado: (2022)

Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer’s Disease Continuum
por: Chen, Yi-He, et al.
Publicado: (2022)

Microglial Immunometabolism in Alzheimer’s Disease
por: Shippy, Daniel C., et al.
Publicado: (2020)

Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer’s disease
por: Baron, Rona, et al.
Publicado: (2014)

A Maitake (Grifola frondosa) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance
por: Bai, Yao, et al.
Publicado: (2019)

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism
por: Zheng, Honghua, et al.
Publicado: (2018)

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
por: Zhong, Li, et al.
Publicado: (2019)

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder
por: Zhang, Lijuan, et al.
Publicado: (2018)

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance
por: Pan, Rui-Yuan, et al.
Publicado: (2019)

DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity
por: Choi, Chiyeol, et al.
Publicado: (2022)

The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology
por: Lau, Shun-Fat, et al.
Publicado: (2023)

An oncogenic role for microRNA-146b in the thyroid
por: Ramírez-Moya, Julia, et al.
Publicado: (2018)

Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer’s disease and brain aging
por: Corraliza-Gomez, Miriam, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ka3rgt0hikj1mmvrcp2s50noid