Cargando…

Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response

IL-4 induces Akt activation in macrophages, required for full M2 (alternative) polarization. We examined the roles of Gαi1 and Gαi3 in M2 polarization using multiple genetic methods. Methods and Results: In MEFs and primary murine BMDMs, Gαi1/3 shRNA, knockout or dominant negative mutations attenuat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bai, Jin-yu, Li, Ya, Xue, Guan-hua, Li, Ke-ran, Zheng, Yu-Fan, Zhang, Zhi-qing, Jiang, Qin, Liu, Yuan-yuan, Zhou, Xiao-zhong, Cao, Cong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978294/ https://www.ncbi.nlm.nih.gov/pubmed/33754034 http://dx.doi.org/10.7150/thno.56383

Ejemplares similares

Neuronal-driven glioma growth requires Gαi1 and Gαi3
por: Wang, Yin, et al.
Publicado: (2021)

SCF/c-Kit-activated signaling and angiogenesis require Gαi1 and Gαi3
por: Shan, Hua-jian, et al.
Publicado: (2023)

Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis
por: Sun, Jian, et al.
Publicado: (2018)

Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis
por: Li, Ya, et al.
Publicado: (2023)

Stabilization of Interdomain Interactions in G protein α(i) Subunits Determines Gα(i) Subtype Signaling Specificity
por: Lefevre, Tyler J., et al.
Publicado: (2023)

A New Generation of FRET Sensors for Robust Measurement of Gα(i1), Gα(i2) and Gα(i3) Activation Kinetics in Single Cells
por: van Unen, Jakobus, et al.
Publicado: (2016)

Generation of Gαi knock-out HEK293 cells illuminates Gαi-coupling diversity of GPCRs
por: Ono, Yuki, et al.
Publicado: (2023)

Gαi3 nuclear translocation causes irradiation resistance in human glioma cells
por: Cai, Shang, et al.
Publicado: (2017)

Sensing and avoiding sick conspecifics requires Gαi2(+) vomeronasal neurons
por: Weiss, Jan, et al.
Publicado: (2023)

Gα(i2)- and Gα(i3)-Specific Regulation of Voltage-Dependent L-Type Calcium Channels in Cardiomyocytes
por: Dizayee, Sara, et al.
Publicado: (2011)

Gα(i2)- and Gα(i3)-Deficient Mice Display Opposite Severity of Myocardial Ischemia Reperfusion Injury
por: Köhler, David, et al.
Publicado: (2014)

Identification of Gαi3 as a promising target for osteosarcoma treatment
por: Bian, Zheng-jun, et al.
Publicado: (2022)

Correction: Gα(i2)- and Gα(i3)-Specific Regulation of Voltage-Dependent L-Type Calcium Channels in Cardiomyocytes
por: Dizayee, Sara, et al.
Publicado: (2013)

Correction: Gα(i2)- and Gα(i3)-Deficient Mice Display Opposite Severity of Myocardial Ischemia Reperfusion Injury
Publicado: (2015)

G against Glioma: G protein inhibitory α subunit 2 (Gαi2) as a novel glioma target
por: Markopoulos, Georgios S.
Publicado: (2023)

G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis
por: Lei, Run, et al.
Publicado: (2016)

CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in G(αs)-G(αi) coupling to the β(2)-adrenergic receptor
por: Ge, Mingli, et al.
Publicado: (2023)

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif
por: de Opakua, Alain Ibáñez, et al.
Publicado: (2017)

Beyond the G protein α subunit: investigating the functional impact of other components of the Gαi(3) heterotrimers
por: Rysiewicz, Beata, et al.
Publicado: (2023)

Interplay between the heterotrimeric G-protein subunits G(αq )and G(αi2 )sets the threshold for chemotaxis and TCR activation
por: Ngai, Jacob, et al.
Publicado: (2009)

Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Gαi1/3-Akt signaling
por: Chen, Zhi-guo, et al.
Publicado: (2023)

Requirement of Gα(q)/Gα(11) Signaling in the Preservation of Mouse Intestinal Epithelial Homeostasis
por: Watanabe, Noboru, et al.
Publicado: (2016)

Structural Basis of the Interaction of the G Proteins, Gαi(1), Gβ(1)γ(2) and Gαi(1)β(1)γ(2), with Membrane Microdomains and Their Relationship to Cell Localization and Activity
por: Álvarez, Rafael, et al.
Publicado: (2023)

Unusually persistent Gα(i)-signaling of the neuropeptide Y(2) receptor depletes cellular G(i/o) pools and leads to a G(i)-refractory state
por: Ziffert, Isabelle, et al.
Publicado: (2020)

Gαi1/3 mediation of Akt-mTOR activation is important for RSPO3-induced angiogenesis
por: Xu, Gang, et al.
Publicado: (2022)

Identification of Gαi3 as a novel molecular therapeutic target of cervical cancer
por: Zhang, Jie, et al.
Publicado: (2022)

Gα(i) is required for carvedilol-induced β(1) adrenergic receptor β-arrestin biased signaling
por: Wang, Jialu, et al.
Publicado: (2017)

Gα(i)-derived peptide binds the µ-opioid receptor
por: Kossoń, Piotr, et al.
Publicado: (2023)

Inhibitory Effects of PEI-RGD/(125)I-(α(V)) ASODN on Growth and Invasion of HepG2 Cells
por: Cai, Haidong, et al.
Publicado: (2015)

Distinct roles of Gαi and Gβ13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions
por: Yu, Fengwei, et al.
Publicado: (2003)

Gα(12) and Gα(13): Versatility in Physiology and Pathology
por: Guo, Paipai, et al.
Publicado: (2022)

Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2
por: Bissinger, Rosi, et al.
Publicado: (2016)

Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα)
por: Burgoyne, Joseph R., et al.
Publicado: (2017)

Transposition and Intermingling of Gαi2 and Gαo Afferences into Single Vomeronasal Glomeruli in the Madagascan Lesser Tenrec Echinops telfairi
por: Suárez, Rodrigo, et al.
Publicado: (2009)

Normal Autophagic Activity in Macrophages from Mice Lacking Gα(i3), AGS3, or RGS19
por: Vural, Ali, et al.
Publicado: (2013)

Unrestrained Gα(i2) Signaling Disrupts Neutrophil Trafficking, Aging, and Clearance
por: Yan, Serena Li-Sue, et al.
Publicado: (2021)

Redox signalling by protein kinase G Iα in cardiovascular physiology and pathology
por: Eaton, Philip
Publicado: (2013)

Gαi3-Dependent Inhibition of JNK Activity on Intracellular Membranes
por: Bastin, Guillaume, et al.
Publicado: (2015)

Molecular architecture of the Gα(i)-bound TRPC5 ion channel
por: Won, Jongdae, et al.
Publicado: (2023)

The PAR2 inhibitor I-287 selectively targets Gα(q) and Gα(12/13) signaling and has anti-inflammatory effects
por: Avet, Charlotte, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_3unt77vnus4dm92k31g0pi594d