Aurka loss in CD19(+) B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production

Rationale: Aurora kinase A (Aurora-A), which is required for mitosis, is a therapeutic target in various tumors. Targeting Aurora-A led to an increase in the differentiation and polyploidization of megakaryocytes both in vivo and in vitro. However, the mechanisms involved in controlling megakaryocyt...

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Detalles Bibliográficos
Autores principales: Chen, Xin, Wang, Chennan, Sun, Na, Pan, Shuai, Li, Rongqing, Li, Xueqin, Zhao, Jie, Tong, Huan, Tang, Yangyang, Han, Jing, Qiao, Jianlin, Qiu, Hongbin, Wang, Hui, Yang, Jing, Ikezoe, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978311/
https://www.ncbi.nlm.nih.gov/pubmed/33754019
http://dx.doi.org/10.7150/thno.49007

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