The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration

The Hippo-YAP pathway responds to diverse environmental cues to manage tissue homeostasis, organ regeneration, tumorigenesis, and immunity. However, how phosphatase(s) directly target Yes-associated protein (YAP) and determine its physiological activity are still inconclusive. Here, we utilized an u...

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Detalles Bibliográficos
Autores principales: Zhou, Ruyuan, Wu, Qirou, Wang, Mengqiu, Irani, Seema, Li, Xiao, Zhang, Qian, Meng, Fansen, Liu, Shengduo, Zhang, Fei, Wu, Liming, Lin, Xia, Wang, Xiaojian, Zou, Jian, Song, Hai, Qin, Jun, Liang, Tingbo, Feng, Xin-Hua, Zhang, Yan Jessie, Xu, Pinglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978383/
https://www.ncbi.nlm.nih.gov/pubmed/33630828
http://dx.doi.org/10.1371/journal.pbio.3001122

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