Massive clonal expansion of polycytotoxic skin and blood CD8(+) T cells in patients with toxic epidermal necrolysis patients

Toxic epidermal necrolysis (TEN) is a life-threatening cutaneous adverse drug reaction. To better understand why skin symptoms are so severe, we conducted a prospective immunophenotyping study on skin and blood. Mass cytometry results confirmed that effector memory polycytotoxic CD8(+) T cells (CTLs...

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Detalles Bibliográficos
Autores principales: Villani, Axel Patrice, Rozieres, Aurore, Bensaid, Benoît, Eriksson, Klara Kristin, Mosnier, Amandine, Albert, Floriane, Mutez, Virginie, Brassard, Océane, Baysal, Tugba, Tardieu, Mathilde, Allatif, Omran, Fusil, Floriane, Andrieu, Thibault, Jullien, Denis, Dubois, Valérie, Giannoli, Catherine, Gruffat, Henri, Pallardy, Marc, Cosset, François-Loïc, Nosbaum, Audrey, Kanagawa, Osami, Maryanski, Janet L., Yerly, Daniel, Nicolas, Jean-François, Vocanson, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978430/
https://www.ncbi.nlm.nih.gov/pubmed/33741590
http://dx.doi.org/10.1126/sciadv.abe0013

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