Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

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Vaccination against SARS-CoV-2 provides an effective tool to combat the COVID-19 pandemic. Here, we combined antigen optimization and nanoparticle display to develop vaccine candidates for SARS-CoV-2. We first displayed the receptor-binding domain (RBD) on three self-assembling protein nanoparticle...

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Detalles Bibliográficos
Autores principales: He, Linling, Lin, Xiaohe, Wang, Ying, Abraham, Ciril, Sou, Cindy, Ngo, Timothy, Zhang, Yi, Wilson, Ian A., Zhu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978432/
https://www.ncbi.nlm.nih.gov/pubmed/33741598
http://dx.doi.org/10.1126/sciadv.abf1591

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