Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial

BACKGROUND: The antifungal drug itraconazole exerts in vitro activity against SARS-CoV-2 in Vero and human Caco-2 cells. Preclinical and clinical studies are required to investigate if itraconazole is effective for the treatment and/or prevention of COVID-19. METHODS: Due to the initial absence of p...

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Detalles Bibliográficos
Autores principales: Liesenborghs, Laurens, Spriet, Isabel, Jochmans, Dirk, Belmans, Ann, Gyselinck, Iwein, Teuwen, Laure-Anne, ter Horst, Sebastiaan, Dreesen, Erwin, Geukens, Tatjana, Engelen, Matthias M., Landeloos, Ewout, Geldhof, Vincent, Ceunen, Helga, Debaveye, Barbara, Vandenberk, Bert, Van der Linden, Lorenz, Jacobs, Sofie, Langendries, Lana, Boudewijns, Robbert, Do, Thuc Nguyen Dan, Chiu, Winston, Wang, Xinyu, Zhang, Xin, Weynand, Birgit, Vanassche, Thomas, Devos, Timothy, Meyfroidt, Geert, Janssens, Wim, Vos, Robin, Vermeersch, Pieter, Wauters, Joost, Verbeke, Geert, De Munter, Paul, Kaptein, Suzanne J.F., Rocha-Pereira, Joana, Delang, Leen, Van Wijngaerden, Eric, Neyts, Johan, Verhamme, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979145/
https://www.ncbi.nlm.nih.gov/pubmed/33752127
http://dx.doi.org/10.1016/j.ebiom.2021.103288

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