Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering

An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral anti...

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Detalles Bibliográficos
Autores principales: Farina, A., Labriola, R., Ialongo, C., Suppa, M., Viggiani, V., Lucarelli, M., Anastasi, E., Angeloni, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institut Pasteur. Published by Elsevier Masson SAS. 2021
Materias:
COVID-19 Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979272/
https://www.ncbi.nlm.nih.gov/pubmed/33753206
http://dx.doi.org/10.1016/j.micinf.2021.104808
Descripción
Sumario:An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.

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