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Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury

Acute respiratory distress syndrome (ARDS) is a devastating pulmonary disease with significant in-hospital mortality and is the leading cause of death in COVID-19 patients. Excessive leukocyte recruitment, unregulated inflammation, and resultant fibrosis contribute to poor ARDS outcomes. Nanoparticl...

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Autores principales: Niemiec, Stephen M., Hilton, Sarah A., Wallbank, Alison, Azeltine, Mark, Louiselle, Amanda E., Elajaili, Hanan, Allawzi, Ayed, Xu, Junwang, Mattson, Courtney, Dewberry, Lindel C., Hu, Junyi, Singh, Sushant, Sakthivel, Tamil S, Sea, Sudipta, Nozik-Grayck, Eva, Smith, Bradford, Zgheib, Carlos, Liechty, Kenneth W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979277/
https://www.ncbi.nlm.nih.gov/pubmed/33753282
http://dx.doi.org/10.1016/j.nano.2021.102388
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author Niemiec, Stephen M.
Hilton, Sarah A.
Wallbank, Alison
Azeltine, Mark
Louiselle, Amanda E.
Elajaili, Hanan
Allawzi, Ayed
Xu, Junwang
Mattson, Courtney
Dewberry, Lindel C.
Hu, Junyi
Singh, Sushant
Sakthivel, Tamil S
Sea, Sudipta
Nozik-Grayck, Eva
Smith, Bradford
Zgheib, Carlos
Liechty, Kenneth W.
author_facet Niemiec, Stephen M.
Hilton, Sarah A.
Wallbank, Alison
Azeltine, Mark
Louiselle, Amanda E.
Elajaili, Hanan
Allawzi, Ayed
Xu, Junwang
Mattson, Courtney
Dewberry, Lindel C.
Hu, Junyi
Singh, Sushant
Sakthivel, Tamil S
Sea, Sudipta
Nozik-Grayck, Eva
Smith, Bradford
Zgheib, Carlos
Liechty, Kenneth W.
author_sort Niemiec, Stephen M.
collection PubMed
description Acute respiratory distress syndrome (ARDS) is a devastating pulmonary disease with significant in-hospital mortality and is the leading cause of death in COVID-19 patients. Excessive leukocyte recruitment, unregulated inflammation, and resultant fibrosis contribute to poor ARDS outcomes. Nanoparticle technology with cerium oxide nanoparticles (CNP) offers a mechanism by which unstable therapeutics such as the anti-inflammatory microRNA-146a can be locally delivered to the injured lung without systemic uptake. In this study, we evaluated the potential of the radical scavenging CNP conjugated to microRNA-146a (termed CNP-miR146a) in preventing acute lung injury (ALI) following exposure to bleomycin. We have found that intratracheal delivery of CNP-miR146a increases pulmonary levels of miR146a without systemic increases, and prevents ALI by altering leukocyte recruitment, reducing inflammation and oxidative stress, and decreasing collagen deposition, ultimately improving pulmonary biomechanics.
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spelling pubmed-79792772021-03-23 Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury Niemiec, Stephen M. Hilton, Sarah A. Wallbank, Alison Azeltine, Mark Louiselle, Amanda E. Elajaili, Hanan Allawzi, Ayed Xu, Junwang Mattson, Courtney Dewberry, Lindel C. Hu, Junyi Singh, Sushant Sakthivel, Tamil S Sea, Sudipta Nozik-Grayck, Eva Smith, Bradford Zgheib, Carlos Liechty, Kenneth W. Nanomedicine Original Article Acute respiratory distress syndrome (ARDS) is a devastating pulmonary disease with significant in-hospital mortality and is the leading cause of death in COVID-19 patients. Excessive leukocyte recruitment, unregulated inflammation, and resultant fibrosis contribute to poor ARDS outcomes. Nanoparticle technology with cerium oxide nanoparticles (CNP) offers a mechanism by which unstable therapeutics such as the anti-inflammatory microRNA-146a can be locally delivered to the injured lung without systemic uptake. In this study, we evaluated the potential of the radical scavenging CNP conjugated to microRNA-146a (termed CNP-miR146a) in preventing acute lung injury (ALI) following exposure to bleomycin. We have found that intratracheal delivery of CNP-miR146a increases pulmonary levels of miR146a without systemic increases, and prevents ALI by altering leukocyte recruitment, reducing inflammation and oxidative stress, and decreasing collagen deposition, ultimately improving pulmonary biomechanics. Elsevier 2021-06 2021-03-20 /pmc/articles/PMC7979277/ /pubmed/33753282 http://dx.doi.org/10.1016/j.nano.2021.102388 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Niemiec, Stephen M.
Hilton, Sarah A.
Wallbank, Alison
Azeltine, Mark
Louiselle, Amanda E.
Elajaili, Hanan
Allawzi, Ayed
Xu, Junwang
Mattson, Courtney
Dewberry, Lindel C.
Hu, Junyi
Singh, Sushant
Sakthivel, Tamil S
Sea, Sudipta
Nozik-Grayck, Eva
Smith, Bradford
Zgheib, Carlos
Liechty, Kenneth W.
Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury
title Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury
title_full Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury
title_fullStr Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury
title_full_unstemmed Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury
title_short Cerium oxide nanoparticle delivery of microRNA-146a for local treatment of acute lung injury
title_sort cerium oxide nanoparticle delivery of microrna-146a for local treatment of acute lung injury
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979277/
https://www.ncbi.nlm.nih.gov/pubmed/33753282
http://dx.doi.org/10.1016/j.nano.2021.102388
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