Atypical Nodular Pulmonary Kappa Light-Chain Deposition

We report a case of an incidental positron emission tomography avid right middle lobe lesion which was increasing in size. Due to concerns regarding malignancy, the patient underwent right middle lobectomy. Microscopic examination showed a 12 × 10 × 10 mm poorly circumscribed lesion composed of eosi...

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Detalles Bibliográficos
Autores principales: Nellipudi, Jessy, Brealey, John, Klebe, Sonja, Lance, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979308/
https://www.ncbi.nlm.nih.gov/pubmed/33777471
http://dx.doi.org/10.1155/2021/5578885
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author Nellipudi, Jessy
Brealey, John
Klebe, Sonja
Lance, David
author_facet Nellipudi, Jessy
Brealey, John
Klebe, Sonja
Lance, David
author_sort Nellipudi, Jessy
collection PubMed
description We report a case of an incidental positron emission tomography avid right middle lobe lesion which was increasing in size. Due to concerns regarding malignancy, the patient underwent right middle lobectomy. Microscopic examination showed a 12 × 10 × 10 mm poorly circumscribed lesion composed of eosinophilic material. The material labelled strongly for kappa light chains; however, Congo red stain was only weakly positive and without “apple-green” positive birefringence under polarised light. Electron microscopy revealed fibrillar amyloid-like material. The features were those of kappa light-chain deposition.
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spelling pubmed-79793082021-03-26 Atypical Nodular Pulmonary Kappa Light-Chain Deposition Nellipudi, Jessy Brealey, John Klebe, Sonja Lance, David Case Rep Pathol Case Report We report a case of an incidental positron emission tomography avid right middle lobe lesion which was increasing in size. Due to concerns regarding malignancy, the patient underwent right middle lobectomy. Microscopic examination showed a 12 × 10 × 10 mm poorly circumscribed lesion composed of eosinophilic material. The material labelled strongly for kappa light chains; however, Congo red stain was only weakly positive and without “apple-green” positive birefringence under polarised light. Electron microscopy revealed fibrillar amyloid-like material. The features were those of kappa light-chain deposition. Hindawi 2021-03-10 /pmc/articles/PMC7979308/ /pubmed/33777471 http://dx.doi.org/10.1155/2021/5578885 Text en Copyright © 2021 Jessy Nellipudi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nellipudi, Jessy
Brealey, John
Klebe, Sonja
Lance, David
Atypical Nodular Pulmonary Kappa Light-Chain Deposition
title Atypical Nodular Pulmonary Kappa Light-Chain Deposition
title_full Atypical Nodular Pulmonary Kappa Light-Chain Deposition
title_fullStr Atypical Nodular Pulmonary Kappa Light-Chain Deposition
title_full_unstemmed Atypical Nodular Pulmonary Kappa Light-Chain Deposition
title_short Atypical Nodular Pulmonary Kappa Light-Chain Deposition
title_sort atypical nodular pulmonary kappa light-chain deposition
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979308/
https://www.ncbi.nlm.nih.gov/pubmed/33777471
http://dx.doi.org/10.1155/2021/5578885
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AT brealeyjohn atypicalnodularpulmonarykappalightchaindeposition
AT klebesonja atypicalnodularpulmonarykappalightchaindeposition
AT lancedavid atypicalnodularpulmonarykappalightchaindeposition

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