Cargando…

Dynamic Regulation of Tfh Selection During the Germinal Center Reaction

The germinal center is a dynamic microenvironment wherein B cells expressing high affinity antibody variants produced by somatic hypermutation are selected for clonal expansion by limiting numbers of T follicular helper cells (1,2). Although much is known about the mechanisms that control B cell sel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Merkenschlager, Julia, Finkin, Shlomo, Ramos, Victor, Kraft, Julian, Cipolla, Melissa, Nowosad, Carla R., Hartweger, Harald, Zhang, Wenzhu, Olinares, Paul Dominic B., Gazumyan, Anna, Oliveira, Thiago Y., Chait, Brian T., Nussenzweig, Michel C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979475/ https://www.ncbi.nlm.nih.gov/pubmed/33536617 http://dx.doi.org/10.1038/s41586-021-03187-x

Ejemplares similares

B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection
por: Chen, Spencer T., et al.
Publicado: (2023)

Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers
por: Merkenschlager, Julia, et al.
Publicado: (2023)

Role of affinity in plasma cell development in the germinal center light zone
por: ElTanbouly, Mohamed A., et al.
Publicado: (2023)

Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients
por: Duan, Ya-qi, et al.
Publicado: (2020)

Germinal center–dependent and –independent memory B cells produced throughout the immune response
por: Viant, Charlotte, et al.
Publicado: (2021)

Tfh1 Cells in Germinal Centers During Chronic HIV/SIV Infection
por: Velu, Vijayakumar, et al.
Publicado: (2018)

The transcriptional program during germinal center reaction - a close view at GC B cells, Tfh cells and Tfr cells
por: Betzler, Annika C., et al.
Publicado: (2023)

Enhanced SARS-CoV-2 Neutralization by Secretory IgA in vitro
por: Wang, Zijun, et al.
Publicado: (2020)

Enhanced SARS-CoV-2 neutralization by dimeric IgA
por: Wang, Zijun, et al.
Publicado: (2021)

Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells
por: Zhang, Yang, et al.
Publicado: (2018)

HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells
por: Hartweger, Harald, et al.
Publicado: (2019)

Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells
por: Kräutler, Nike J., et al.
Publicado: (2017)

Regulators of Tfh Cell Differentiation
por: Jogdand, Gajendra M., et al.
Publicado: (2016)

TFH cells in systemic sclerosis
por: Beurier, Pauline, et al.
Publicado: (2021)

Germinal center B cells recognize antigen through a specialized immune synapse architecture
por: Nowosad, Carla R., et al.
Publicado: (2016)

A follicular regulatory Innate Lymphoid Cell population impairs interactions between germinal center Tfh and B cells
por: O’Connor, Margaret H., et al.
Publicado: (2021)

Germinal Center T follicular helper (GC-Tfh) cell impairment in chronic HIV infection involves c-Maf signaling
por: Chakhtoura, Marita, et al.
Publicado: (2021)

Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4(+) T cell fate
por: Zhu, Fangming, et al.
Publicado: (2023)

Regulation of class switch recombination and somatic mutation by AID phosphorylation
por: McBride, Kevin M., et al.
Publicado: (2008)

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination
por: Cho, Alice, et al.
Publicado: (2021)

Circulating memory T follicular helper subsets, Tfh2 and Tfh17, participate in the pathogenesis of Guillain-Barré syndrome
por: Che, Yuanyuan, et al.
Publicado: (2016)

Longitudinal clonal dynamics of HIV-1 latent reservoirs measured by combination quadruplex polymerase chain reaction and sequencing
por: Cho, Alice, et al.
Publicado: (2022)

The MIDAS domain of AAA mechanoenzyme Mdn1 forms catch bonds with two different substrates
por: Mickolajczyk, Keith J, et al.
Publicado: (2022)

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection
por: Wang, Zijun, et al.
Publicado: (2021)

Functions of Tfh Cells in Common Variable Immunodeficiency
por: Le Saos-Patrinos, Corentin, et al.
Publicado: (2020)

Structural basis of substrate recognition by a polypeptide processing and secretion transporter
por: Kieuvongngam, Virapat, et al.
Publicado: (2020)

Distinct gene expression by expanded clones of quiescent memory CD4(+) T cells harboring intact latent HIV-1 proviruses
por: Weymar, Georg H.J., et al.
Publicado: (2022)

Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma
por: Pontarini, Elena, et al.
Publicado: (2020)

Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells
por: Sekiya, Takashi, et al.
Publicado: (2015)

Circulating Tfh1 (cTfh1) cell numbers and PD1 expression are elevated in low-grade B-cell non-Hodgkin’s lymphoma and cTfh gene expression is perturbed in marginal zone lymphoma
por: Byford, Elliot T., et al.
Publicado: (2018)

A nucleotide binding–independent role for γ-tubulin in microtubule capping and cell division
por: Berman, Adi Y., et al.
Publicado: (2023)

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies
por: Muecksch, Frauke, et al.
Publicado: (2021)

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
por: Muecksch, Frauke, et al.
Publicado: (2021)

Case Report: IL-21 and Bcl-6 Regulate the Proliferation and Secretion of Tfh and Tfr Cells in the Intestinal Germinal Center of Patients With Inflammatory Bowel Disease
por: Yang, Youguang, et al.
Publicado: (2021)

Type I Interferons Promote Germinal Centers Through B Cell Intrinsic Signaling and Dendritic Cell Dependent Th1 and Tfh Cell Lineages
por: Dahlgren, Madelene W., et al.
Publicado: (2022)

Translational regulation of TFH cell differentiation and autoimmune pathogenesis
por: Patel, Preeyam S., et al.
Publicado: (2022)

Deciphering the spectrum of cutaneous lymphomas expressing TFH markers
por: Donzel, Marie, et al.
Publicado: (2023)

Igβ tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization
por: Gazumyan, Anna, et al.
Publicado: (2006)

The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators
por: Orlova, Natalia, et al.
Publicado: (2017)

Analysis of the mechanosensor channel functionality of TACAN
por: Niu, Yiming, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_obch0n9v35gu41ebct0504i8ba