Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis

Targeted therapies for gastrointestinal stromal tumor (GIST) are modestly effective, but GIST cannot be cured with single agent tyrosine kinase inhibitors. In this study, we sought to identify new therapeutic targets in GIST by investigating the tumor microenvironment. Here, we identified a paracrin...

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Detalles Bibliográficos
Autores principales: Yoon, Hyunho, Tang, Chih-Min, Banerjee, Sudeep, Yebra, Mayra, Noh, Sangkyu, Burgoyne, Adam M., Torre, Jorge De la, Siena, Martina De, Liu, Mengyuan, Klug, Lillian R., Choi, Yoon Young, Hosseini, Mojgan, Delgado, Antonio L., Wang, Zhiyong, French, Randall P., Lowy, Andrew, DeMatteo, Ronald P., Heinrich, Michael C., Molinolo, Alfredo A., Gutkind, J. Silvio, Harismendy, Olivier, Sicklick, Jason K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979540/
https://www.ncbi.nlm.nih.gov/pubmed/33603171
http://dx.doi.org/10.1038/s41388-021-01685-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979540/
https://www.ncbi.nlm.nih.gov/pubmed/33603171
http://dx.doi.org/10.1038/s41388-021-01685-w

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