Cargando…

Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters

OBJECTIVE: To identify textural features on dual-energy CT (DECT)–based bone marrow images in myeloma which correlate with serum markers of myeloma activity and the degree of medullary involvement. METHODS: A total of 110 patients (63.0 ± 11.0 years, 51 female) who underwent unenhanced whole-body DE...

Descripción completa

Detalles Bibliográficos
Autores principales: Reinert, Christian Philipp, Krieg, Eva, Esser, Michael, Nikolaou, Konstantin, Bösmüller, Hans, Horger, Marius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979667/
https://www.ncbi.nlm.nih.gov/pubmed/33011876
http://dx.doi.org/10.1007/s00330-020-07320-8
_version_ 1783667309411303424
author Reinert, Christian Philipp
Krieg, Eva
Esser, Michael
Nikolaou, Konstantin
Bösmüller, Hans
Horger, Marius
author_facet Reinert, Christian Philipp
Krieg, Eva
Esser, Michael
Nikolaou, Konstantin
Bösmüller, Hans
Horger, Marius
author_sort Reinert, Christian Philipp
collection PubMed
description OBJECTIVE: To identify textural features on dual-energy CT (DECT)–based bone marrow images in myeloma which correlate with serum markers of myeloma activity and the degree of medullary involvement. METHODS: A total of 110 patients (63.0 ± 11.0 years, 51 female) who underwent unenhanced whole-body DECT between September 2015 and February 2019 were retrospectively included, which was approved by our institutional ethics committee with a waiver of the informed consent requirement. All patients had current hematologic laboratory tests. Using DECT post-processing, non-calcium bone marrow images were reconstructed. The vertebral bodies T10–L5 were segmented for quantification of textural features, which were compared with serologic parameters and myeloma stages by the Mann-Whitney U test. In a subgroup of 56/110 patients with current bone marrow biopsies, textural features were correlated with the degree of bone marrow infiltration. RESULTS: First-order features were higher in patients with advanced stage of myeloma (p < .02), whereas the 2nd-order “gray-level co-occurrence matrix (GLCM) cluster prominence” was lower (p < .04). In patients with elevated serum-free light chains (SFLC) or kappa/lambda SFLC ratio above 1.56, the “entropy” and 2nd-order GLCM features were lower (p < .03). The degree of bone marrow infiltration correlated with 1st-order features (e.g., “uniformity”; r(P) = 0.49; p < .0001), whereas “entropy” and 2nd-order GLCM features were negatively correlated (e.g., “difference entropy”; r(P) = − 0.54; p < .0001). CONCLUSIONS: CT textural features applied on non-calcium bone marrow images correlate well with myeloma-related serologic parameters and histology showing a more uniform tissue structure and higher attenuation with increasing medullary infiltration and could therefore be used as additional imaging biomarkers for non-invasive assessment of medullary involvement. KEY POINTS: • Texture analysis applied on dual-energy reconstructed non-calcium bone marrow images provides information about marrow structure and attenuation. • Myeloma-related serologic parameters and the degree of myeloma cell infiltration correlate with 1st- and 2nd-order features which could be useful as additional imaging biomarkers for non-invasive assessment of medullary involvement. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00330-020-07320-8) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-7979667
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-79796672021-04-05 Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters Reinert, Christian Philipp Krieg, Eva Esser, Michael Nikolaou, Konstantin Bösmüller, Hans Horger, Marius Eur Radiol Computed Tomography OBJECTIVE: To identify textural features on dual-energy CT (DECT)–based bone marrow images in myeloma which correlate with serum markers of myeloma activity and the degree of medullary involvement. METHODS: A total of 110 patients (63.0 ± 11.0 years, 51 female) who underwent unenhanced whole-body DECT between September 2015 and February 2019 were retrospectively included, which was approved by our institutional ethics committee with a waiver of the informed consent requirement. All patients had current hematologic laboratory tests. Using DECT post-processing, non-calcium bone marrow images were reconstructed. The vertebral bodies T10–L5 were segmented for quantification of textural features, which were compared with serologic parameters and myeloma stages by the Mann-Whitney U test. In a subgroup of 56/110 patients with current bone marrow biopsies, textural features were correlated with the degree of bone marrow infiltration. RESULTS: First-order features were higher in patients with advanced stage of myeloma (p < .02), whereas the 2nd-order “gray-level co-occurrence matrix (GLCM) cluster prominence” was lower (p < .04). In patients with elevated serum-free light chains (SFLC) or kappa/lambda SFLC ratio above 1.56, the “entropy” and 2nd-order GLCM features were lower (p < .03). The degree of bone marrow infiltration correlated with 1st-order features (e.g., “uniformity”; r(P) = 0.49; p < .0001), whereas “entropy” and 2nd-order GLCM features were negatively correlated (e.g., “difference entropy”; r(P) = − 0.54; p < .0001). CONCLUSIONS: CT textural features applied on non-calcium bone marrow images correlate well with myeloma-related serologic parameters and histology showing a more uniform tissue structure and higher attenuation with increasing medullary infiltration and could therefore be used as additional imaging biomarkers for non-invasive assessment of medullary involvement. KEY POINTS: • Texture analysis applied on dual-energy reconstructed non-calcium bone marrow images provides information about marrow structure and attenuation. • Myeloma-related serologic parameters and the degree of myeloma cell infiltration correlate with 1st- and 2nd-order features which could be useful as additional imaging biomarkers for non-invasive assessment of medullary involvement. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00330-020-07320-8) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-10-03 2021 /pmc/articles/PMC7979667/ /pubmed/33011876 http://dx.doi.org/10.1007/s00330-020-07320-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Computed Tomography
Reinert, Christian Philipp
Krieg, Eva
Esser, Michael
Nikolaou, Konstantin
Bösmüller, Hans
Horger, Marius
Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters
title Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters
title_full Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters
title_fullStr Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters
title_full_unstemmed Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters
title_short Role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters
title_sort role of computed tomography texture analysis using dual-energy-based bone marrow imaging for multiple myeloma characterization: comparison with histology and established serologic parameters
topic Computed Tomography
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979667/
https://www.ncbi.nlm.nih.gov/pubmed/33011876
http://dx.doi.org/10.1007/s00330-020-07320-8
work_keys_str_mv AT reinertchristianphilipp roleofcomputedtomographytextureanalysisusingdualenergybasedbonemarrowimagingformultiplemyelomacharacterizationcomparisonwithhistologyandestablishedserologicparameters
AT kriegeva roleofcomputedtomographytextureanalysisusingdualenergybasedbonemarrowimagingformultiplemyelomacharacterizationcomparisonwithhistologyandestablishedserologicparameters
AT essermichael roleofcomputedtomographytextureanalysisusingdualenergybasedbonemarrowimagingformultiplemyelomacharacterizationcomparisonwithhistologyandestablishedserologicparameters
AT nikolaoukonstantin roleofcomputedtomographytextureanalysisusingdualenergybasedbonemarrowimagingformultiplemyelomacharacterizationcomparisonwithhistologyandestablishedserologicparameters
AT bosmullerhans roleofcomputedtomographytextureanalysisusingdualenergybasedbonemarrowimagingformultiplemyelomacharacterizationcomparisonwithhistologyandestablishedserologicparameters
AT horgermarius roleofcomputedtomographytextureanalysisusingdualenergybasedbonemarrowimagingformultiplemyelomacharacterizationcomparisonwithhistologyandestablishedserologicparameters