Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature

We present current knowledge concerning the pharmacogenomics of growth hormone therapy in children with short stature. We consider the evidence now emerging for the polygenic nature of response to recombinant human growth hormone (r-hGH). These data are related predominantly to the use of transcript...

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Autores principales: Stevens, Adam, Perchard, Reena, Garner, Terence, Clayton, Peter, Murray, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979669/
https://www.ncbi.nlm.nih.gov/pubmed/33712998
http://dx.doi.org/10.1007/s11154-021-09637-1
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author Stevens, Adam
Perchard, Reena
Garner, Terence
Clayton, Peter
Murray, Philip
author_facet Stevens, Adam
Perchard, Reena
Garner, Terence
Clayton, Peter
Murray, Philip
author_sort Stevens, Adam
collection PubMed
description We present current knowledge concerning the pharmacogenomics of growth hormone therapy in children with short stature. We consider the evidence now emerging for the polygenic nature of response to recombinant human growth hormone (r-hGH). These data are related predominantly to the use of transcriptomic data for prediction. The impact of the complex interactions of developmental phenotype over childhood on response to r-hGH are discussed. Finally, the issues that need to be addressed in order to develop a clinical test are described.
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spelling pubmed-79796692021-04-05 Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature Stevens, Adam Perchard, Reena Garner, Terence Clayton, Peter Murray, Philip Rev Endocr Metab Disord Article We present current knowledge concerning the pharmacogenomics of growth hormone therapy in children with short stature. We consider the evidence now emerging for the polygenic nature of response to recombinant human growth hormone (r-hGH). These data are related predominantly to the use of transcriptomic data for prediction. The impact of the complex interactions of developmental phenotype over childhood on response to r-hGH are discussed. Finally, the issues that need to be addressed in order to develop a clinical test are described. Springer US 2021-03-12 2021 /pmc/articles/PMC7979669/ /pubmed/33712998 http://dx.doi.org/10.1007/s11154-021-09637-1 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Stevens, Adam
Perchard, Reena
Garner, Terence
Clayton, Peter
Murray, Philip
Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature
title Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature
title_full Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature
title_fullStr Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature
title_full_unstemmed Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature
title_short Pharmacogenomics applied to recombinant human growth hormone responses in children with short stature
title_sort pharmacogenomics applied to recombinant human growth hormone responses in children with short stature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979669/
https://www.ncbi.nlm.nih.gov/pubmed/33712998
http://dx.doi.org/10.1007/s11154-021-09637-1
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