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Stabilisation of half MCM ring by Cdt1 during DNA insertion

Origin licensing ensures precise once per cell cycle replication in eukaryotic cells. The Origin Recognition Complex, Cdc6 and Cdt1 load Mcm2-7 helicase (MCM) into a double hexamer, bound around duplex DNA. The complex formed by ORC-Cdc6 bound to duplex DNA (OC) recruits the MCM-Cdt1 complex into th...

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Detalles Bibliográficos
Autores principales:	Guerrero-Puigdevall, Marina, Fernandez-Fuentes, Narcis, Frigola, Jordi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979726/ https://www.ncbi.nlm.nih.gov/pubmed/33741931 http://dx.doi.org/10.1038/s41467-021-21932-8

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