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The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics
Microfluidics exploiting the phenomenon of inertial focusing have attracted much attention in the last decade as they provide the means to facilitate the detection and analysis of rare particles of interest in complex fluids such as blood and natural water. Although many interesting applications hav...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979744/ https://www.ncbi.nlm.nih.gov/pubmed/33742075 http://dx.doi.org/10.1038/s41598-021-85910-2 |
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author | Cruz, Javier Hjort, Klas |
author_facet | Cruz, Javier Hjort, Klas |
author_sort | Cruz, Javier |
collection | PubMed |
description | Microfluidics exploiting the phenomenon of inertial focusing have attracted much attention in the last decade as they provide the means to facilitate the detection and analysis of rare particles of interest in complex fluids such as blood and natural water. Although many interesting applications have been demonstrated, the systems remain difficult to engineer. A recently presented line of the technology, inertial focusing in High Aspect Ratio Curved microfluidics, has the potential to change this and make the benefits of inertial focusing more accessible to the community. In this paper, with experimental evidence and fluid simulations, we provide the two necessary equations to design the systems and successfully focus the targets in a single, stable, and high-quality position. The experiments also revealed an interesting scaling law of the lift force, which we believe provides a valuable insight into the phenomenon of inertial focusing. |
format | Online Article Text |
id | pubmed-7979744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79797442021-03-25 The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics Cruz, Javier Hjort, Klas Sci Rep Article Microfluidics exploiting the phenomenon of inertial focusing have attracted much attention in the last decade as they provide the means to facilitate the detection and analysis of rare particles of interest in complex fluids such as blood and natural water. Although many interesting applications have been demonstrated, the systems remain difficult to engineer. A recently presented line of the technology, inertial focusing in High Aspect Ratio Curved microfluidics, has the potential to change this and make the benefits of inertial focusing more accessible to the community. In this paper, with experimental evidence and fluid simulations, we provide the two necessary equations to design the systems and successfully focus the targets in a single, stable, and high-quality position. The experiments also revealed an interesting scaling law of the lift force, which we believe provides a valuable insight into the phenomenon of inertial focusing. Nature Publishing Group UK 2021-03-19 /pmc/articles/PMC7979744/ /pubmed/33742075 http://dx.doi.org/10.1038/s41598-021-85910-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Cruz, Javier Hjort, Klas The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics |
title | The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics |
title_full | The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics |
title_fullStr | The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics |
title_full_unstemmed | The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics |
title_short | The upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics |
title_sort | upper limit and lift force within inertial focusing in high aspect ratio curved microfluidics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979744/ https://www.ncbi.nlm.nih.gov/pubmed/33742075 http://dx.doi.org/10.1038/s41598-021-85910-2 |
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