trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

Bacterial ribosome rescue pathways that remove ribosomes stalled on mRNAs during translation have been proposed as novel antibiotic targets because they are essential in bacteria and are not conserved in humans. We previously reported the discovery of a family of acylaminooxadiazoles that selectivel...

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Detalles Bibliográficos
Autores principales: Aron, Zachary D., Mehrani, Atousa, Hoffer, Eric D., Connolly, Kristie L., Srinivas, Pooja, Torhan, Matthew C., Alumasa, John N., Cabrera, Mynthia, Hosangadi, Divya, Barbor, Jay S., Cardinale, Steven C., Kwasny, Steven M., Morin, Lucas R., Butler, Michelle M., Opperman, Timothy J., Bowlin, Terry L., Jerse, Ann, Stagg, Scott M., Dunham, Christine M., Keiler, Kenneth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979765/
https://www.ncbi.nlm.nih.gov/pubmed/33741965
http://dx.doi.org/10.1038/s41467-021-22012-7

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