Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation

Mechanical stress induced by contractions constantly threatens the integrity of muscle Z-disc, a crucial force-bearing structure in striated muscle. The PDZ-LIM proteins have been proposed to function as adaptors in transducing mechanical signals to preserve the Z-disc structure, however the underly...

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Detalles Bibliográficos
Autores principales: Pathak, Pankaj, Blech-Hermoni, Yotam, Subedi, Kalpana, Mpamugo, Jessica, Obeng-Nyarko, Charissa, Ohman, Rachel, Molloy, Ilda, Kates, Malcolm, Hale, Jessica, Stauffer, Stacey, Sharan, Shyam K., Mankodi, Ami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979776/
https://www.ncbi.nlm.nih.gov/pubmed/33742095
http://dx.doi.org/10.1038/s42003-021-01864-1

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